| Unique identifier for interactor A | uniprotkb:Q9ULZ3 |
| Unique identifier for interactor B | uniprotkb:P29466 |
| Alternative identifier for interactor A | intact:EBI-751215 uniprotkb:Q96D12 uniprotkb:Q9BSZ5 uniprotkb:Q9HBD0 uniprotkb:Q9NXJ8 ensembl:ENSP00000247470.9 |
| Alternative identifier for interactor B | intact:EBI-516667 uniprotkb:B5MDZ1 ensembl:ENSP00000410076.3 ensembl:ENSP00000433138.1 uniprotkb:Q53EY6 uniprotkb:Q6DMQ1 uniprotkb:Q6GSS3 uniprotkb:Q6PI75 uniprotkb:Q9UCN3 |
| Aliases for A | psi-mi:asc_human(display_long) uniprotkb:PYD and CARD domain-containing protein(gene name synonym) uniprotkb:Target of methylation-induced silencing 1(gene name synonym) uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym) uniprotkb:ASC(gene name synonym) uniprotkb:CARD5(gene name synonym) uniprotkb:TMS1(gene name synonym) uniprotkb:PYCARD(gene name) psi-mi:PYCARD(display_short) |
| Aliases for B | psi-mi:casp1_human(display_long) uniprotkb:Interleukin-1 beta convertase(gene name synonym) uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym) uniprotkb:p45(gene name synonym) uniprotkb:CASP1(gene name) psi-mi:CASP1(display_short) uniprotkb:IL1BC(gene name synonym) uniprotkb:IL1BCE(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Suganuma et al. (2022) |
| Identifier of the publication | pubmed:31421660 imex:IM-29530 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-34579649 imex:IM-29530-1 |
| Confidence score | intact-miscore:0.86 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | comment:"\"The amount of NLRP3 bound with PYCARD/ASC was increased by stimulation with PMA or PMA plus MSU in THP-1 cells expressing Δexon2 PYCARD/ASC but was decreased in cells expressing wild-type PYCARD/ASC. There were no changes in caspase-1 binding (Figure 3c).\"" figure legend:Fig. 3C curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-thp-1) taxid:9606(Homo sapiens THP-1 acute monocytic leukemia cell) |
| Parameters of the interaction | - |
| Creation date | 2022/06/15 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |