Curation Details
Interaction ID: IM-29336-54

Unique identifier for interactor Achembl target:CHEMBL1907601
Unique identifier for interactor Buniprotkb:P06400
Alternative identifier for interactor Aintact:EBI-767849
reactome:R-HSA-113844
reactome:R-HSA-75812
reactome:R-HSA-75814
intenz:2.7.11.22
wwpdb:2w9f
wwpdb:2w9z
wwpdb:2w99
wwpdb:2w96
reactome:R-HSA-68331
signor:SIGNOR-C18
Alternative identifier for interactor Bintact:EBI-491274
uniprotkb:P78499
uniprotkb:Q5VW46
uniprotkb:Q8IZL4
uniprotkb:A8K5E3
ensembl:ENSP00000267163.4
Aliases for Apsi-mi:cyclind1_cdk4_human(display_short)
psi-mi:CHEMBL1907601(display_long)
intact:"CCND1:CDK4"(complex systematic name)
intact:Cyclin D1-CDK4 complex(complex recommended name)
Aliases for Bpsi-mi:rb_human(display_long)
uniprotkb:pRb(gene name synonym)
uniprotkb:pp110(gene name synonym)
uniprotkb:p105-Rb(gene name synonym)
uniprotkb:RB1(gene name)
psi-mi:RB1(display_short)
uniprotkb:p110-RB1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0424"(protein kinase assay)
First authorKabuta et al. (2013)
Identifier of the publicationimex:IM-29336
pubmed:23543736
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0217"(phosphorylation reaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-28998079
imex:IM-29336-54
Confidence scoreintact-miscore:0.44
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AEnzyme
Biological role BEnzyme target
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AStable complex
Interactor type BProtein
Annotations for the interactionfigure legend:F2B
curation depth:imex curation
dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.
dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2021/09/30
Update date2024/08/11
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor Bphosphorylated residue:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot