Curation Details
Interaction ID: IM-29336-31

Unique identifier for interactor Auniprotkb:P09936
Unique identifier for interactor Buniprotkb:P11802
Alternative identifier for interactor Aintact:EBI-714860
uniprotkb:Q71UM0
intact:EBI-1049220
uniprotkb:Q4W5K6
ensembl:ENSP00000284440.4
ensembl:ENSP00000422542.1
Alternative identifier for interactor Bintact:EBI-295644
uniprotkb:O00576
uniprotkb:Q6FG61
uniprotkb:B4DNF9
uniprotkb:B2R9A0
ensembl:ENSP00000257904.5
Aliases for Apsi-mi:uchl1_human(display_long)
uniprotkb:Ubiquitin thioesterase L1(gene name synonym)
uniprotkb:Neuron cytoplasmic protein 9.5(gene name synonym)
uniprotkb:PGP 9.5(gene name synonym)
uniprotkb:UCHL1(gene name)
psi-mi:UCHL1(display_short)
Aliases for Bpsi-mi:cdk4_human(display_long)
uniprotkb:CDK4(gene name)
psi-mi:CDK4(display_short)
uniprotkb:Cell division protein kinase 4(gene name synonym)
uniprotkb:PSK-J3(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorKabuta et al. (2013)
Identifier of the publicationimex:IM-29336
pubmed:23543736
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0914"(association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-27121983
imex:IM-29336-31
Confidence scoreintact-miscore:0.59
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F5G
comment:"\"We observed that overexpression of CDK5 attenuated the interaction between overexpressed CDK4 and UCH-L1 (1.5-fold decrease) (Fig. 5G, lanes 2 and 4).\""
curation depth:imex curation
dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.
dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-hela)
taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell)
Parameters of the interaction-
Creation date2021/09/30
Update date2024/11/14
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:c-c
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot