Curation Details
Interaction ID: IM-29336-19

Unique identifier for interactor Auniprotkb:P11802
Unique identifier for interactor Buniprotkb:P38936
Alternative identifier for interactor Aintact:EBI-295644
uniprotkb:Q6FG61
uniprotkb:B4DNF9
uniprotkb:B2R9A0
ensembl:ENSP00000257904.5
uniprotkb:O00576
Alternative identifier for interactor Bintact:EBI-375077
uniprotkb:Q14010
uniprotkb:Q9BUT4
ensembl:ENSP00000244741.6
ensembl:ENSP00000362815.1
ensembl:ENSP00000384849.1
ensembl:ENSP00000409259.3
ensembl:ENSP00000482768.1
uniprotkb:Q6FI05
Aliases for Apsi-mi:cdk4_human(display_long)
uniprotkb:CDK4(gene name)
psi-mi:CDK4(display_short)
uniprotkb:Cell division protein kinase 4(gene name synonym)
uniprotkb:PSK-J3(gene name synonym)
Aliases for Bpsi-mi:cdn1a_human(display_long)
uniprotkb:CDKN1A(gene name)
psi-mi:CDKN1A(display_short)
uniprotkb:CAP20(gene name synonym)
uniprotkb:CDKN1(gene name synonym)
uniprotkb:CIP1(gene name synonym)
uniprotkb:MDA6(gene name synonym)
uniprotkb:PIC1(gene name synonym)
uniprotkb:SDI1(gene name synonym)
uniprotkb:WAF1(gene name synonym)
uniprotkb:p21(gene name synonym)
uniprotkb:CDK-interacting protein 1(gene name synonym)
uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorKabuta et al. (2013)
Identifier of the publicationimex:IM-29336
pubmed:23543736
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-27122092
imex:IM-29336-19
Confidence scoreintact-miscore:0.92
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:SF3D
comment:"\"We also tested whether UCH-L1 competes with the CDK inhibitors p27 (Kip1) or p21 (Cip1) for binding to CDKs. UCH-L1 did not affect the level of interaction between CDK1 and p21, CDK1 and p27, CDK4 and p21, and CDK4 and p27 (supplemental Fig. S3, D and E), indicating that UCH-L1 does not compete with p27 or p21 for the binding to CDKs.\""
dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.
dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9534(chlae-cos_7)
taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)
Parameters of the interaction-
Creation date2021/09/30
Update date2021/11/09
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor Bflag tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot