| Unique identifier for interactor A | uniprotkb:P00441 |
| Unique identifier for interactor B | uniprotkb:P37840 |
| Alternative identifier for interactor A | intact:EBI-990792 ensembl:ENSP00000270142.7 uniprotkb:A6NHJ0 uniprotkb:Q16669 uniprotkb:Q16711 uniprotkb:Q16838 uniprotkb:Q16839 uniprotkb:Q16840 uniprotkb:Q6NR85 uniprotkb:D3DSE4 |
| Alternative identifier for interactor B | intact:EBI-985879 uniprotkb:Q13701 uniprotkb:Q4JHI3 uniprotkb:Q6IAU6 uniprotkb:A8K2A4 ensembl:ENSP00000338345.3 ensembl:ENSP00000378437.1 ensembl:ENSP00000378442.4 ensembl:ENSP00000422238.1 ensembl:ENSP00000426955.1 ensembl:ENSP00000500990.1 |
| Aliases for A | psi-mi:sodc_human(display_long) uniprotkb:Superoxide dismutase 1(gene name synonym) uniprotkb:SOD1(gene name) psi-mi:SOD1(display_short) |
| Aliases for B | psi-mi:syua_human(display_long) uniprotkb:Non-A beta component of AD amyloid(gene name synonym) uniprotkb:Non-A4 component of amyloid precursor(gene name synonym) uniprotkb:SNCA(gene name) psi-mi:SNCA(display_short) uniprotkb:NACP(gene name synonym) uniprotkb:PARK1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:1203"(split luciferase complementation) |
| First author | Helferich et al. (2015) |
| Identifier of the publication | pubmed:26643113 imex:IM-29239 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-27092701 imex:IM-29239-17 |
| Confidence score | intact-miscore:0.57 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Stimulator |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 7b comment:"\"Vice versa we examined if SOD1 promotes α-synuclein oligomerization thereby measuring luciferase activity of H4 cells expressing S1 and S2 with wt or mutated SOD1. We found that wt and G85R SOD1 did not influence the oligomerization of α-synuclein (Fig. 7b). By contrast, G93A SOD1 dramatically increases the α-synuclein oligomerization.\"" curation depth:imex curation full coverage:Only protein-protein interactions dataset:Brain Disease - Neurological Diseases & Disorders dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases. |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-h4) taxid:9606(Homo sapiens H4 neurogioma cell) |
| Parameters of the interaction | - |
| Creation date | 2021/09/21 |
| Update date | 2024/07/30 |
| negative Boolean value | false |
| Feature(s) for interactor A | myc tag:?-? mutation causing an interaction:94-94 |
| Feature(s) for interactor B | gaussia-c:c-c |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Tag visualisation by luciferase assay |
| Participant identification method for interactor B | Tag visualisation by luciferase assay |