| Unique identifier for interactor A | uniprotkb:P00441 |
| Unique identifier for interactor B | uniprotkb:P00441 |
| Alternative identifier for interactor A | intact:EBI-990792 uniprotkb:A6NHJ0 uniprotkb:Q16669 uniprotkb:Q16711 uniprotkb:Q16838 uniprotkb:Q16839 uniprotkb:Q16840 uniprotkb:Q6NR85 uniprotkb:D3DSE4 ensembl:ENSP00000270142.7 |
| Alternative identifier for interactor B | intact:EBI-990792 uniprotkb:A6NHJ0 uniprotkb:Q16669 uniprotkb:Q16711 uniprotkb:Q16838 uniprotkb:Q16839 uniprotkb:Q16840 uniprotkb:Q6NR85 uniprotkb:D3DSE4 ensembl:ENSP00000270142.7 |
| Aliases for A | psi-mi:sodc_human(display_long) uniprotkb:Superoxide dismutase 1(gene name synonym) uniprotkb:SOD1(gene name) psi-mi:SOD1(display_short) |
| Aliases for B | psi-mi:sodc_human(display_long) uniprotkb:Superoxide dismutase 1(gene name synonym) uniprotkb:SOD1(gene name) psi-mi:SOD1(display_short) |
| Interaction detection methods | psi-mi:"MI:1203"(split luciferase complementation) |
| First author | Helferich et al. (2015) |
| Identifier of the publication | pubmed:26643113 imex:IM-29239 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-27092683 imex:IM-29239-15 |
| Confidence score | intact-miscore:0.98 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 7a, 8a,b comment:"\"an increase in SOD1 dimerization was detected when wt, A30P or A53T α-synuclein was co-transfected together with SOD1 (Fig. 7a) whereas the expression level of SOD1-1 and SOD1-2 was not altered (Additional file 5: Figure S5a) suggesting that α-synuclein increases SOD1 dimerization and/or oligomerization.\"" comment:"\"Addition of (untraceable) recombinant SNCA had the same effect\"" curation depth:imex curation full coverage:Only protein-protein interactions dataset:Brain Disease - Neurological Diseases & Disorders dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases. |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-h4) taxid:9606(Homo sapiens H4 neurogioma cell) |
| Parameters of the interaction | - |
| Creation date | 2021/09/21 |
| Update date | 2025/06/23 |
| negative Boolean value | false |
| Feature(s) for interactor A | gaussia-n:c-c |
| Feature(s) for interactor B | gaussia-c:c-c |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Tag visualisation by luciferase assay |
| Participant identification method for interactor B | Tag visualisation by luciferase assay |