| Unique identifier for interactor A | uniprotkb:P00451 |
| Unique identifier for interactor B | uniprotkb:P04275 |
| Alternative identifier for interactor A | intact:EBI-1046394 uniprotkb:Q5HY69 uniprotkb:Q14286 ensembl:ENSP00000353393.4 |
| Alternative identifier for interactor B | intact:EBI-981819 ensembl:ENSP00000261405.5 uniprotkb:Q8TCE8 uniprotkb:Q99806 |
| Aliases for A | psi-mi:fa8_human(display_long) uniprotkb:Procoagulant component(gene name synonym) uniprotkb:Antihemophilic factor(gene name synonym) uniprotkb:F8(gene name) psi-mi:F8(display_short) uniprotkb:F8C(gene name synonym) |
| Aliases for B | psi-mi:vwf_human(display_long) uniprotkb:VWF(gene name) psi-mi:VWF(display_short) uniprotkb:F8VWF(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0107"(surface plasmon resonance) |
| First author | Nguyen et al. (2017) |
| Identifier of the publication | pubmed:27749002 imex:IM-29215 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0407"(direct interaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-27086024 imex:IM-29215-1 |
| Confidence score | intact-miscore:0.62 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:Fig. S5, Table 1 comment:"\"to determine if there was any difference in affinity for VWF between the furin deletion variants and hFVIII-BDD (Figure S5). The KD was 0.7 nM for hFVIII-BDD, 1.4 nM for delta1645, 1.2 nM for delta2, 1.0 nM for delta3, 2.2 nM for delta4 and 0.7 nM for delta1648, demonstrating that the variants may have a similar affinity for VWF.\"" dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | kd:0.7x10^-9(mol) |
| Creation date | 2021/09/11 |
| Update date | 2021/09/11 |
| negative Boolean value | false |
| Feature(s) for interactor A | sufficient binding region:1-797,1562-2351 mutation with no effect:1664-1664 mutation with no effect:1667-1667 mutation with no effect:1664-1665 mutation with no effect:1664-1666 mutation with no effect:1664-1667 |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Predetermined participant |
| Participant identification method for interactor B | Predetermined participant |