Curation Details
Interaction ID: IM-28947-1

Unique identifier for interactor Auniprotkb:Q15389
Unique identifier for interactor Buniprotkb:Q15389
Alternative identifier for interactor Aintact:EBI-2922365
uniprotkb:Q5HYA0
ensembl:ENSP00000428340.1
Alternative identifier for interactor Bintact:EBI-2922365
uniprotkb:Q5HYA0
ensembl:ENSP00000428340.1
Aliases for Apsi-mi:angp1_human(display_long)
uniprotkb:ANGPT1(gene name)
psi-mi:ANGPT1(display_short)
uniprotkb:KIAA0003(gene name synonym)
Aliases for Bpsi-mi:angp1_human(display_long)
uniprotkb:ANGPT1(gene name)
psi-mi:ANGPT1(display_short)
uniprotkb:KIAA0003(gene name synonym)
Interaction detection methodspsi-mi:"MI:0807"(comigration in gel electrophoresis)
First authorThomson et al. (2017)
Identifier of the publicationpubmed:29106382
imex:IM-28947
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26959717
imex:IM-28947-1
Confidence scoreintact-miscore:0.52
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:Fig. 6A
comment:under nonreducing conditions, WT ANGPT1 protein was predominantly grouped in high-order multimers of greater than 250 kDa, consistent with earlier reports
curation depth:imex curation
dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293)
taxid:9606(Homo sapiens HEK293 embryonic kidney cell)
Parameters of the interaction-
Creation date2021/04/22
Update date2024/11/14
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:c-c
mutation with no effect:249-249
mutation disrupting interaction strength:236-498
mutation disrupting interaction strength:494-498
necessary binding region:494-498
Feature(s) for interactor Bflag tag:c-c
mutation with no effect:249-249
mutation disrupting interaction strength:236-498
mutation disrupting interaction strength:494-498
necessary binding region:494-498
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AConfirmation by molecular weight
Participant identification method for interactor BConfirmation by molecular weight