| Unique identifier for interactor A | uniprotkb:O75398 |
| Unique identifier for interactor B | uniprotkb:P51608 |
| Alternative identifier for interactor A | intact:EBI-718185 uniprotkb:A8K5R8 uniprotkb:A8K1F8 uniprotkb:C7T5V5 intact:EBI-28974412 ensembl:ENSP00000371846.3 uniprotkb:O15152 uniprotkb:O75399 uniprotkb:O75510 uniprotkb:O75511 uniprotkb:O75512 uniprotkb:O75513 uniprotkb:Q9UET1 |
| Alternative identifier for interactor B | intact:EBI-1189067 ensembl:ENSP00000301948.6 uniprotkb:O15233 uniprotkb:Q6QHH9 uniprotkb:Q7Z384 |
| Aliases for A | psi-mi:deaf1_human(display_long) uniprotkb:Nuclear DEAF-1-related transcriptional regulator(gene name synonym) uniprotkb:Suppressin(gene name synonym) uniprotkb:Zinc finger MYND domain-containing protein 5(gene name synonym) uniprotkb:DEAF1(gene name) psi-mi:DEAF1(display_short) uniprotkb:SPN(gene name synonym) uniprotkb:ZMYND5(gene name synonym) |
| Aliases for B | psi-mi:mecp2_human(display_long) uniprotkb:MECP2(gene name) psi-mi:MECP2(display_short) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Philippe et al. (2018) |
| Identifier of the publication | pubmed:29636529 imex:IM-28932 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-26970542 imex:IM-28932-5 |
| Confidence score | intact-miscore:0.59 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:suppl. fig 1 comment:"\"To confirm the Deaf1-MeCP2 interaction, IgG, Deaf1, or MeCP2 antibodies were used to immunoprecipitate endogenous proteins from extracts of SKN-SH cells, hippocampal tissue or MEFs from Deaf1 knockout or wild-type mice. MeCP2 was detected in anti-MeCP2 precipitates in all samples, and was enriched when pulling down for Deaf1 in SKN-SH, Deaf1 +/+ MEF and WT hippocampal extracts, but not in Deaf1 −/− MEFs and Deaf1 KO hippocampal tissue (Supplementary Fig. S1). It was not possible to detect Deaf1 due to cross-reactivity with IgG heavy chain, and the lack of a suitable alternate Deaf1 antibody. Taken together, these results indicate that MeCP2 and Deaf1 proteins interact.\"" dataset:Brain Disease - Neurological Diseases & Disorders full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-sk-n-sh) taxid:9606(Homo sapiens SK-N-SH neuroblastoma cell) |
| Parameters of the interaction | - |
| Creation date | 2021/05/04 |
| Update date | 2021/05/05 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |