| Unique identifier for interactor A | uniprotkb:Q9NRI5 |
| Unique identifier for interactor B | uniprotkb:P14416 |
| Alternative identifier for interactor A | intact:EBI-529989 uniprotkb:C9J6D0 intact:EBI-28977396 uniprotkb:A6NLH2 uniprotkb:C4P095 uniprotkb:C4P0A1 uniprotkb:C4P0A3 uniprotkb:C4P0B3 uniprotkb:C4P091 uniprotkb:C4P0B6 uniprotkb:C4P0C1 ensembl:ENSP00000403888.4 uniprotkb:O75045 uniprotkb:Q5VT44 uniprotkb:Q5VT45 uniprotkb:Q8IXJ0 uniprotkb:Q8IXJ1 uniprotkb:Q9BX19 uniprotkb:Q9NRI3 uniprotkb:Q9NRI4 |
| Alternative identifier for interactor B | intact:EBI-2928178 uniprotkb:Q9NZR3 uniprotkb:Q9UPA9 ensembl:ENSP00000354859.3 ensembl:ENSP00000442172.1 |
| Aliases for A | psi-mi:disc1_human(display_long) uniprotkb:DISC1(gene name) psi-mi:DISC1(display_short) uniprotkb:KIAA0457(gene name synonym) |
| Aliases for B | psi-mi:drd2_human(display_long) uniprotkb:DRD2(gene name) psi-mi:DRD2(display_short) uniprotkb:Dopamine D2 receptor(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Su et al. (2020) |
| Identifier of the publication | imex:IM-28924 pubmed:32493513 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-26968759 imex:IM-28924-3 |
| Confidence score | intact-miscore:0.54 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 1 d-f comment:"\"As shown in Fig. 1a, we found that the human R264Q DISC1 variant, but not the control A83V variant located outside the binding domain, is associated with significantly lower DISC1 protein levels compared to wildtype (WT) DISC1, when transfected into HEK-293 T cells. However, DISC1- D2R complex levels are significantly increased in DISC1R264Q (Fig. 1a-c), but not DISC1A83V (Fig. 1d-f)\"" dataset:Brain Disease - Neurological Diseases & Disorders dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293t) taxid:9606(Homo sapiens HEK293T embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2021/04/29 |
| Update date | 2021/05/03 |
| negative Boolean value | false |
| Feature(s) for interactor A | flag tag:?-? mutation decreasing interaction:83-83 |
| Feature(s) for interactor B | ha tag:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Anti tag western blot |
| Participant identification method for interactor B | Anti tag western blot |