Curation Details
Interaction ID: IM-28915-3

Unique identifier for interactor Auniprotkb:P10275
Unique identifier for interactor Buniprotkb:Q08117
Alternative identifier for interactor Aintact:EBI-608057
uniprotkb:B1AKD7
uniprotkb:Q9UD95
intact:EBI-11476138
uniprotkb:A0A0B4J1T2
uniprotkb:C0JKD3
uniprotkb:C0JKD4
uniprotkb:E7EVX6
ensembl:ENSP00000363822.3
ensembl:ENSP00000484033.2
uniprotkb:A2RUN2
Alternative identifier for interactor Bintact:EBI-717810
uniprotkb:B2RBL0
ensembl:ENSP00000317537.4
uniprotkb:Q14CJ1
uniprotkb:Q12808
uniprotkb:Q96TG9
uniprotkb:Q9UDY9
Aliases for Apsi-mi:andr_human(display_long)
uniprotkb:Dihydrotestosterone receptor(gene name synonym)
uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)
uniprotkb:AR(gene name)
psi-mi:AR(display_short)
uniprotkb:DHTR(gene name synonym)
uniprotkb:NR3C4(gene name synonym)
Aliases for Bpsi-mi:tle5_human(display_long)
uniprotkb:TLE5(gene name)
psi-mi:TLE5(display_short)
uniprotkb:AES(gene name synonym)
uniprotkb:Amino-terminal enhancer of split(gene name synonym)
uniprotkb:GRG(gene name synonym)
uniprotkb:GRG5(gene name synonym)
uniprotkb:Gp130-associated protein GAM(gene name synonym)
uniprotkb:Grg-5(gene name synonym)
uniprotkb:Groucho-related protein 5(gene name synonym)
uniprotkb:Protein ESP1(gene name synonym)
uniprotkb:Protein GRG(gene name synonym)
uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)
Interaction detection methodspsi-mi:"MI:1314"(proximity-dependent biotin identification)
First authorVélot et al. (2021)
Identifier of the publicationimex:IM-28915
pubmed:33640491
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:2364"(proximity)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26965611
imex:IM-28915-3
Confidence scoreintact-miscore:0.27
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:"\"Only high-confidence interactions (SAINT score ≤0.9) were considered for follow-up experiments and analyses (supplemental Fig. 1A). We identified 31 proteins associated with AR in the absence of agonist (Fig. 2, supplemental Table S1). Strikingly, we also found that 182 and 200 (261 nonredundant) proteins were associated with AR upon stimulation with DHT for 24h or 72h, respectively\""
figure legend:ST1
agonist:"\"17β-hydroxy-5α-androstan-3-one (CHEBI:16330)\""
comment:"\"Cells were treated with DHT (10 nM) for 24 h\""
dataset:Cancer - Interactions investigated in the context of cancer
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-lapc4)
taxid:9606(Homo sapiens LAPC4 prostate carcinoma cell)
Parameters of the interaction-
Creation date2021/04/27
Update date2022/05/31
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:n-n
fusion protein:n-n
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ASequence tag identification
Participant identification method for interactor BSequence tag identification