Curation Details
Interaction ID: IM-28889-15

Unique identifier for interactor Auniprotkb:Q99608
Unique identifier for interactor Buniprotkb:Q92616
Alternative identifier for interactor Aintact:EBI-718177
ensembl:ENSP00000497916.1
uniprotkb:B2R6Z5
Alternative identifier for interactor Bintact:EBI-356221
intact:EBI-1058692
ensembl:ENSP00000300648.6
uniprotkb:O95001
uniprotkb:O95651
uniprotkb:Q6P2S3
uniprotkb:Q86X65
uniprotkb:Q8N5I5
uniprotkb:Q8WU80
uniprotkb:Q99736
uniprotkb:Q9UE60
uniprotkb:A8KAY1
Aliases for Apsi-mi:necd_human(display_long)
uniprotkb:NDN(gene name)
psi-mi:NDN(display_short)
Aliases for Bpsi-mi:gcn1_human(display_long)
uniprotkb:GCN1(gene name)
psi-mi:GCN1(display_short)
uniprotkb:GCN1 eIF-2-alpha kinase activator homolog(gene name synonym)
uniprotkb:GCN1-like protein 1(gene name synonym)
uniprotkb:GCN1L1(gene name synonym)
uniprotkb:General control of amino-acid synthesis 1-like protein 1(gene name synonym)
uniprotkb:KIAA0219(gene name synonym)
uniprotkb:Translational activator GCN1(gene name synonym)
Interaction detection methodspsi-mi:"MI:1314"(proximity-dependent biotin identification)
First authorSanderson et al. (2020)
Identifier of the publicationimex:IM-28889
pubmed:32529326
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:2364"(proximity)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26957193
imex:IM-28889-15
Confidence scoreintact-miscore:0.27
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F6B
comment:"\"We eliminated proteins found in only one of three replicate samples or present at high levels in a contaminant repository for affinity purification-mass spectrometry data (CRAPome Mellacheruvu et al. 2013). In all, 24 proteins were carried forward as necdin-proximate proteins.\""
dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease
dataset:Brain Disease - Neurological Diseases & Disorders
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293flp-in)
taxid:9606(Homo sapiens HEK293flp-in embryonic kidney cell)
Parameters of the interaction-
Creation date2021/02/19
Update date2022/03/24
negative Boolean valuefalse
Feature(s) for interactor Amutation with complex effect:265-265
fusion protein:c-c
flag tag:c-c
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ASequence tag identification
Participant identification method for interactor BSequence tag identification