| Unique identifier for interactor A | uniprotkb:P61158 |
| Unique identifier for interactor B | uniprotkb:Q8K1M6-3 |
| Alternative identifier for interactor A | intact:EBI-351428 uniprotkb:P32391 uniprotkb:Q53QM2 ensembl:ENSP00000263238.2 intact:EBI-21359005 |
| Alternative identifier for interactor B | intact:EBI-16092613 ensembl:ENSMUSP00000023477.8 |
| Aliases for A | psi-mi:arp3_human(display_long) uniprotkb:ACTR3(gene name) psi-mi:ACTR3(display_short) uniprotkb:ARP3(gene name synonym) uniprotkb:Actin-like protein 3(gene name synonym) |
| Aliases for B | psi-mi:q8k1m6-3(display_long) uniprotkb:Dnm1l(gene name) psi-mi:Dnm1l(display_short) uniprotkb:Drp1(gene name synonym) uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym) uniprotkb:Dynamin-related protein 1(gene name synonym) uniprotkb:S-Drp1(isoform synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Galvan et al. (2019) |
| Identifier of the publication | imex:IM-28850 pubmed:31063459 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:10090(mouse) taxid:10090(Mus musculus) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-26880519 imex:IM-28850-1 |
| Confidence score | intact-miscore:0.40 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:Fig. 7A comment:"\"To this end, we transfected GFP-tagged Arp3 into cultured podocytes stably expressing empty vector control, FLAG-tagged WT Drp1S600, or Drp1S600 mutants (S600A or S600D). Western blot detection of the immunoprecipitated FLAG-tagged proteins indicted that the interaction of Drp1 with the GFP-Arp3 complex was markedly increased in cells that were cultured in HG conditions and in Drp1S600D-transfected podocytes (Figure 7A). However, this interaction was markedly reduced in FLAG-Drp1S600A cells under HG conditions, suggesting that, indeed, the binding of Drp1 to the Arp3 complex was enhanced by the phosphorylation of Drp1S600.\"" agonist:"\"high-glucose (CHEBI:17234)\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:10090(mouse-podocyte) taxid:10090(Mus musculus) |
| Parameters of the interaction | - |
| Creation date | 2021/03/18 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | green fluorescent protein tag:c-c |
| Feature(s) for interactor B | flag tag:?-? mutation decreasing interaction strength:600-600 mutation increasing interaction strength:600-600 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Anti tag western blot |
| Participant identification method for interactor B | Anti tag western blot |