| Unique identifier for interactor A | uniprotkb:P34896 |
| Unique identifier for interactor B | uniprotkb:P50213 |
| Alternative identifier for interactor A | intact:EBI-715117 uniprotkb:Q9UMD1 uniprotkb:Q9UMD2 uniprotkb:Q96HY0 uniprotkb:D3DXD0 uniprotkb:B4DPM9 ensembl:ENSP00000318868.3 ensembl:ENSP00000462041.2 ensembl:ENSP00000492715.2 ensembl:ENSP00000518786.1 |
| Alternative identifier for interactor B | intact:EBI-355999 uniprotkb:D3DW83 uniprotkb:Q9H3X0 ensembl:ENSP00000299518.2 |
| Aliases for A | psi-mi:glyc_human(display_long) uniprotkb:Glycine hydroxymethyltransferase(gene name synonym) uniprotkb:SHMT1(gene name) psi-mi:SHMT1(display_short) uniprotkb:Serine methylase(gene name synonym) |
| Aliases for B | psi-mi:idh3a_human(display_long) uniprotkb:IDH3A(gene name) psi-mi:IDH3A(display_short) uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym) uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | May et al. (2019) |
| Identifier of the publication | imex:IM-28811 pubmed:30613765 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-26876442 imex:IM-28811-9 |
| Confidence score | intact-miscore:0.46 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | comment:"\"The IDH3a interactome was defined using IP-MS studies in patient-derived GICs, expressing a scrambled or an IDH3a- targeting shRNA. Peptides derived from four proteins were reproducibly detected in shScr-expressing GICs upon IDH3a-specific pulldown, but not in immunoglobulin G (IgG) isotype-matched control precipitates or in GICs stably expressing shRNA targeted to IDH3a (Fig. 4, D and E). Among the four candidates, cSHMT was the only IDH3a interactor that coprecipitated with IDH3a in all transformed GBM cell lines, patient-derived GICs, and NHAs.\"" figure legend:fig. 4d curation depth:imex curation dataset:Brain Disease - Neurological Diseases & Disorders full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-glioblastoma brain tumour-initiating cell) taxid:9606("Homo sapiens glioblastoma brain tumour-initiating cell (GBM-BTIC)") |
| Parameters of the interaction | - |
| Creation date | 2021/02/22 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Sequence tag identification |
| Participant identification method for interactor B | Sequence tag identification |