Curation Details
Interaction ID: IM-28771-17

Unique identifier for interactor Auniprotkb:P51608-1
Unique identifier for interactor Buniprotkb:O88508
Alternative identifier for interactor Aintact:EBI-26687319
ensembl:ENSP00000301948.6
Alternative identifier for interactor Bintact:EBI-995154
ensembl:ENSMUSP00000020991.9
ensembl:ENSMUSP00000134009.2
uniprotkb:Q3UH24
uniprotkb:Q8CJ60
uniprotkb:Q922J0
uniprotkb:Q9CSE1
uniprotkb:Q3TZK8
Aliases for Apsi-mi:p51608-1(display_long)
uniprotkb:MECP2(gene name)
psi-mi:MECP2(display_short)
uniprotkb:Beta(isoform synonym)
Aliases for Bpsi-mi:dnm3a_mouse(display_long)
uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)
uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)
uniprotkb:Dnmt3a(gene name)
psi-mi:Dnmt3a(display_short)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorRajavelu et al. (2018)
Identifier of the publicationpubmed:30102379
imex:IM-28771
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:10090(mouse)
taxid:10090(Mus musculus)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26687535
imex:IM-28771-17
Confidence scoreintact-miscore:0.65
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F6B
comment:addition of histone H3 abolished the ADD–TRD interaction, suggesting that H3 and TRD binding to the ADD domain is mutually exclusive.
dataset:Brain Disease - Neurological Diseases & Disorders
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2021/02/24
Update date2021/03/09
negative Boolean valuefalse
Feature(s) for interactor Aglutathione s tranferase tag:n-n
sufficient binding region:170-325
Feature(s) for interactor Bhis tag:n-n
sufficient binding region:220-908
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AMolecular weight estimation by coomasie staining
Participant identification method for interactor BMolecular weight estimation by coomasie staining