Curation Details
Interaction ID: IM-28737-26

Unique identifier for interactor Auniprotkb:Q99650
Unique identifier for interactor Buniprotkb:P28331
Alternative identifier for interactor Aintact:EBI-2804080
uniprotkb:Q96QJ6
uniprotkb:Q6P4E8
ensembl:ENSP00000274276.3
Alternative identifier for interactor Bintact:EBI-1043922
uniprotkb:B4DJA0
uniprotkb:B4DIN9
uniprotkb:E7ENF3
ensembl:ENSP00000490898.1
ensembl:ENSP00000233190.5
ensembl:ENSP00000399912.1
ensembl:ENSP00000489640.1
uniprotkb:B4DPG1
uniprotkb:B4DUC1
uniprotkb:Q53TR8
uniprotkb:Q8N1C4
uniprotkb:Q8TCC9
Aliases for Apsi-mi:osmr_human(display_long)
uniprotkb:OSMRB(gene name synonym)
uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)
uniprotkb:OSMR(gene name)
psi-mi:OSMR(display_short)
Aliases for Bpsi-mi:ndus1_human(display_long)
uniprotkb:NDUFS1(gene name)
psi-mi:NDUFS1(display_short)
uniprotkb:Complex I-75kD(gene name synonym)
Interaction detection methodspsi-mi:"MI:0813"(proximity ligation assay)
First authorSharanek et al. (2020)
Identifier of the publicationpubmed:32807793
imex:IM-28737
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26875869
imex:IM-28737-26
Confidence scoreintact-miscore:0.50
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig.2 q
comment:"\"the interactions of OSMR with either NDUFS1 or NDUFS2 were validated by PLA in different patient-derived BTSCs (Fig. 2p, q). Furthermore, we confirmed that the mitochondria is the site of interaction of OSMR/NDUFS1 and OSMR/NDUFS2 as revealed by double labeling of the PLA signal with the MitoTracker (Fig. 2r, s).\""
dataset:Brain Disease - Neurological Diseases & Disorders
dataset:Cancer - Interactions investigated in the context of cancer
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-btsc147)
taxid:9606(Homo sapiens BTSC147 brain tumor stem cell)
Parameters of the interaction-
Creation date2021/02/15
Update date2021/03/24
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AIdentification by antibody
Participant identification method for interactor BIdentification by antibody