Curation Details
Interaction ID: IM-28737-24

Unique identifier for interactor Auniprotkb:Q99650
Unique identifier for interactor Buniprotkb:P38646
Alternative identifier for interactor Aintact:EBI-2804080
uniprotkb:Q96QJ6
uniprotkb:Q6P4E8
ensembl:ENSP00000274276.3
Alternative identifier for interactor Bintact:EBI-354932
ensembl:ENSP00000297185.3
uniprotkb:P30036
uniprotkb:P31932
uniprotkb:Q6GU03
uniprotkb:Q9BWB7
uniprotkb:B2RCM1
uniprotkb:Q1HB43
uniprotkb:Q53H23
uniprotkb:Q9UC56
Aliases for Apsi-mi:osmr_human(display_long)
uniprotkb:OSMRB(gene name synonym)
uniprotkb:Interleukin-31 receptor subunit beta(gene name synonym)
uniprotkb:OSMR(gene name)
psi-mi:OSMR(display_short)
Aliases for Bpsi-mi:grp75_human(display_long)
uniprotkb:HSPA9(gene name)
psi-mi:HSPA9(display_short)
uniprotkb:GRP75(gene name synonym)
uniprotkb:HSPA9B(gene name synonym)
uniprotkb:75 kDa glucose-regulated protein(gene name synonym)
uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)
uniprotkb:Peptide-binding protein 74(gene name synonym)
uniprotkb:Mortalin(gene name synonym)
uniprotkb:mt-HSP70(gene name synonym)
Interaction detection methodspsi-mi:"MI:0813"(proximity ligation assay)
First authorSharanek et al. (2020)
Identifier of the publicationpubmed:32807793
imex:IM-28737
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26875863
imex:IM-28737-24
Confidence scoreintact-miscore:0.50
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig.2 h
comment:"\"Next, we performed PLA analysis using antibodies to OSMR and mtHSP70. Significant PLA signal was detected in BTSC73 and 147 (Fig. 2g, h), and the PLA interaction signal was found in puncti with the mitochondria as revealed by co-staining of the BTSC73 with MitoTracker (Fig. 2i).\""
dataset:Brain Disease - Neurological Diseases & Disorders
dataset:Cancer - Interactions investigated in the context of cancer
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-btsc147)
taxid:9606(Homo sapiens BTSC147 brain tumor stem cell)
Parameters of the interaction-
Creation date2021/02/15
Update date2021/03/12
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AIdentification by antibody
Participant identification method for interactor BIdentification by antibody