| Unique identifier for interactor A | uniprotkb:P11021 |
| Unique identifier for interactor B | uniprotkb:Q9H173 |
| Alternative identifier for interactor A | intact:EBI-354921 uniprotkb:B0QZ61 ensembl:ENSP00000324173.6 uniprotkb:Q2EF78 uniprotkb:Q9NPF1 uniprotkb:Q9UK02 |
| Alternative identifier for interactor B | intact:EBI-2840325 uniprotkb:Q8N2L3 uniprotkb:D3DQC2 ensembl:ENSP00000265195.5 ensembl:ENSP00000378294.2 |
| Aliases for A | psi-mi:bip_human(display_long) uniprotkb:HSPA5(gene name) psi-mi:HSPA5(display_short) uniprotkb:GRP78(gene name synonym) uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym) uniprotkb:78 kDa glucose-regulated protein(gene name synonym) uniprotkb:Binding-immunoglobulin protein(gene name synonym) uniprotkb:Heat shock protein 70 family protein 5(gene name synonym) uniprotkb:Heat shock protein family A member 5(gene name synonym) |
| Aliases for B | psi-mi:sil1_human(display_long) uniprotkb:SIL1(gene name) psi-mi:SIL1(display_short) uniprotkb:BiP-associated protein(gene name synonym) uniprotkb:UNQ545/PRO836(orf name) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Inaguma et al. (2014) |
| Identifier of the publication | pubmed:24473200 imex:IM-28723 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-26617794 imex:IM-28723-3 |
| Confidence score | intact-miscore:0.67 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:Fig. 2B caution:"\"We reported host organism to be HEK293 cells as described in methods and in Figure legend, however, text mentions the experiment has been carried out in COS-7 cells ('To test this possibility, interaction of these mutants with HSPA5 was analyzed in vitro by immunoprecipitation following co-expression in COS7 cells. As shown in Fig 2B, these mutations significantly diminished the binding capacity of SIL1 to HSPA5 when compared to wild type SIL1 and a SIL1-related protein HSPBP1').\"" dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease dataset:Brain Disease - Neurological Diseases & Disorders full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293) taxid:9606(Homo sapiens HEK293 embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2021/02/09 |
| Update date | 2021/02/09 |
| negative Boolean value | false |
| Feature(s) for interactor A | green fluorescent protein tag:?-? |
| Feature(s) for interactor B | flag tag:?-? mutation decreasing interaction strength:457-457 mutation decreasing interaction strength:411-415 mutation decreasing interaction strength:352-461 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Anti tag western blot |
| Participant identification method for interactor B | Anti tag western blot |