Curation Details
Interaction ID: IM-28722-38

Unique identifier for interactor Auniprotkb:P61006
Unique identifier for interactor Buniprotkb:Q8TEV9
Alternative identifier for interactor Aintact:EBI-722293
uniprotkb:B4DEK7
intact:EBI-21356948
ensembl:ENSP00000300935.2
intact:EBI-1054454
uniprotkb:P24407
intact:EBI-2798283
uniprotkb:Q6FHV5
Alternative identifier for interactor Bintact:EBI-2961718
uniprotkb:A5PKZ5
uniprotkb:Q3ZCN0
uniprotkb:Q6PJL3
ensembl:ENSP00000385025.3
ensembl:ENSP00000492062.1
Aliases for Apsi-mi:rab8a_human(display_long)
uniprotkb:Oncogene c-mel(gene name synonym)
uniprotkb:RAB8A(gene name)
psi-mi:RAB8A(display_short)
uniprotkb:MEL(gene name synonym)
uniprotkb:RAB8(gene name synonym)
Aliases for Bpsi-mi:smcr8_human(display_long)
uniprotkb:SMCR8(gene name)
psi-mi:SMCR8(display_short)
uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorSellier et al. (2016)
Identifier of the publicationimex:IM-28722
pubmed:27103069
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26618938
imex:IM-28722-38
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig 1d EV1d-e
comment:"\"Further coimmunoprecipitation assays indicated that the interaction between C9ORF72 complex and RAB8a or RAB39b is mainly dependent on the presence of SMCR8 since C9ORF72 or WDR41 alone immunoprecipitated little RAB8a or no RAB39b (Fig EV1D).\""
dataset:Brain Disease - Neurological Diseases & Disorders
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293)
taxid:9606(Homo sapiens HEK293 embryonic kidney cell)
Parameters of the interaction-
Creation date2021/01/18
Update date2021/02/10
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:n-n
Feature(s) for interactor Bha tag:c-c
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AAnti tag western blot
Participant identification method for interactor BAnti tag western blot