| Unique identifier for interactor A | uniprotkb:Q96LT7 |
| Unique identifier for interactor B | uniprotkb:Q8TEV9 |
| Alternative identifier for interactor A | intact:EBI-2961725 uniprotkb:Q6NUS9 uniprotkb:A8K5W0 uniprotkb:D3DRK6 uniprotkb:G8I0B6 ensembl:ENSP00000369339.3 ensembl:ENSP00000482753.1 |
| Alternative identifier for interactor B | intact:EBI-2961718 uniprotkb:A5PKZ5 uniprotkb:Q3ZCN0 uniprotkb:Q6PJL3 ensembl:ENSP00000385025.3 ensembl:ENSP00000492062.1 |
| Aliases for A | psi-mi:ci072_human(display_long) uniprotkb:C9orf72(gene name) psi-mi:C9orf72(display_short) uniprotkb:DENND9(gene name synonym) uniprotkb:DENNL72(gene name synonym) |
| Aliases for B | psi-mi:smcr8_human(display_long) uniprotkb:SMCR8(gene name) psi-mi:SMCR8(display_short) uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 8 protein(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0424"(protein kinase assay) |
| First author | Sellier et al. (2016) |
| Identifier of the publication | imex:IM-28722 pubmed:27103069 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0217"(phosphorylation reaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-26618650 imex:IM-28722-14 |
| Confidence score | intact-miscore:0.85 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Stimulator |
| Biological role B | Enzyme target |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig 3c comment:"\"In vitro kinase assay demonstrated that TBK1 phosphorylates SMCR8, but not C9ORF72 or WDR41 (Fig 3B). We repeated that experiment using purified TBK1 overexpressed from HEK293 cells and recombinant HIS‐C9ORF72, SMCR8, and WDR41 complex purified from baculovirus‐infected insect cells. Mass spectrometry analysis identified SMCR8 serine 402 and threonine 796 as TBK1 phosphorylation sites (Fig 3C)\"" dataset:Brain Disease - Neurological Diseases & Disorders curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2021/01/18 |
| Update date | 2025/03/26 |
| negative Boolean value | false |
| Feature(s) for interactor A | his tag:?-? |
| Feature(s) for interactor B | O-phospho-L-serine:402-402 O-phospho-L-threonine:796-796 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Identification by mass spectrometry |
| Participant identification method for interactor B | Identification by mass spectrometry |