| Unique identifier for interactor A | uniprotkb:Q8BIZ1 |
| Unique identifier for interactor B | uniprotkb:P26443 |
| Alternative identifier for interactor A | intact:EBI-16724439 uniprotkb:E9Q644 uniprotkb:Q4KMR9 uniprotkb:Q8BJ47 uniprotkb:Q8BJ49 |
| Alternative identifier for interactor B | intact:EBI-773329 uniprotkb:Q8C273 ensembl:ENSMUSP00000022322.10 |
| Aliases for A | psi-mi:ans1b_mouse(display_long) uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym) uniprotkb:E2A-PBX1-associated protein(gene name synonym) uniprotkb:Anks1b(gene name) psi-mi:Anks1b(display_short) |
| Aliases for B | psi-mi:dhe3_mouse(display_long) uniprotkb:Glud1(gene name) psi-mi:Glud1(display_short) uniprotkb:Glud(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Carbonell et al. (2019) |
| Identifier of the publication | pubmed:31388001 imex:IM-28644 |
| NCBI Taxonomy identifier for interactor A | taxid:10090(mouse) taxid:10090(Mus musculus) |
| NCBI Taxonomy identifier for interactor B | taxid:10090(mouse) taxid:10090(Mus musculus) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-26595802 imex:IM-28644-1 |
| Confidence score | intact-miscore:0.35 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:suppl data 6b; fig. 4 comment:"\"We performed ten unique immunoprecipitations (IPs) from mouse brain lysates using control IgGs, AIDA-1 IgGs, and antibodies to unrelated synaptic proteins crosslinked to protein G-agarose or magnetic beads. Each eluted IP sample was labeled with a unique isobaric tag within a 10-plex set of tandem mass tags43. This approach allowed us to accurately quantify identified peptides, simultaneously analyze all samples to reduce variability associated with mass spectrometry (MS) analysis, and rigorously control for nonspecific binding by normalizing to control IgG samples and comparing to unrelated protein interactomes (Supplementary Data 6a). We used a commercially available antibody (C-10, Santa Cruz Biotechnologies), as well as in-house antibodies known to immunoprecipitate AIDA-1 (1A11 and 2B22) (Fig. 4b). We defined the AIDA-1 interactome as proteins co-immunoprecipitated by AIDA-1 antibodies that were identified and quantified by ≥3 peptides and enriched >1.4-fold over background in agarose experiments, or >3.0-fold in magnetic bead experiments (Supplementary Data 6b).\"" curation depth:imex curation dataset:Brain Disease - Neurological Diseases & Disorders full coverage:Only protein-protein interactions dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn |
| NCBI Taxonomy identifier for the host organism | taxid:10090(mouse-brain) taxid:10090(Mus musculus brain) |
| Parameters of the interaction | - |
| Creation date | 2021/01/18 |
| Update date | 2024/08/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Identification by mass spectrometry |
| Participant identification method for interactor B | Identification by mass spectrometry |