Curation Details
Interaction ID: IM-28573-3

Unique identifier for interactor Auniprotkb:P0DP23
Unique identifier for interactor Buniprotkb:Q5JU85
Alternative identifier for interactor Aintact:EBI-25817233
uniprotkb:P02593
uniprotkb:P62158
uniprotkb:P70667
uniprotkb:P99014
uniprotkb:Q13942
uniprotkb:Q53S29
uniprotkb:Q61379
uniprotkb:Q61380
uniprotkb:Q96HK3
intact:EBI-28973196
ensembl:ENSP00000349467.4
Alternative identifier for interactor Bintact:EBI-11028607
uniprotkb:B3KT97
uniprotkb:C7SDG1
uniprotkb:Q5JUX1
uniprotkb:O60275
uniprotkb:A0A1W2PQN3
ensembl:ENSP00000495726.1
ensembl:ENSP00000502054.1
Aliases for Apsi-mi:calm1_human(display_long)
uniprotkb:CALM1(gene name)
psi-mi:CALM1(display_short)
uniprotkb:CALM(gene name synonym)
uniprotkb:CAM(gene name synonym)
uniprotkb:CAM1(gene name synonym)
Aliases for Bpsi-mi:iqec2_human(display_long)
uniprotkb:IQSEC2(gene name)
psi-mi:IQSEC2(display_short)
uniprotkb:KIAA0522(gene name synonym)
Interaction detection methodspsi-mi:"MI:0729"(luminescence based mammalian interactome mapping)
First authorRogers et al. (2018)
Identifier of the publicationimex:IM-28573
pubmed:30842726
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26564800
imex:IM-28573-3
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:Fig. 2
comment:The binding of calmodulin to wild type and A350V IQSEC2 is increased by calcium.
agonist:"\"CHEBI:29108 - calcium(2+)\""
dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease
dataset:"\"Autism - Autism, or autism spectrum disorder (ASD), refers to a broad range of conditions characterized by challenges with social skills, repetitive behaviors, speech and nonverbal communication.\""
dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293t)
taxid:9606(Homo sapiens HEK293T embryonic kidney cell)
Parameters of the interaction-
Creation date2020/12/15
Update date2020/12/15
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:c-c
Feature(s) for interactor Bmutation disrupting interaction strength:350-350
renilla luciferase protein tag:n-n
ha tag:n-n
mutation disrupting interaction strength:359-359
mutation disrupting interaction strength:354-355,359-359
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ATag visualisation by luciferase assay
Participant identification method for interactor BTag visualisation by luciferase assay