Curation Details
Interaction ID: IM-28561-95

Unique identifier for interactor Auniprotkb:Q9UHC7
Unique identifier for interactor Buniprotkb:P49815
Alternative identifier for interactor Aintact:EBI-373524
uniprotkb:A4D1T7
uniprotkb:B3KXB4
uniprotkb:Q256Y7
uniprotkb:Q59G11
uniprotkb:Q9UHW2
ensembl:ENSP00000255977.2
uniprotkb:Q6GSF1
uniprotkb:Q9H0G0
uniprotkb:Q9UEZ7
Alternative identifier for interactor Bintact:EBI-396587
uniprotkb:A7E2E2
uniprotkb:B4DIQ7
uniprotkb:B4DRN2
uniprotkb:Q4LE71
uniprotkb:C9J378
uniprotkb:B4DIL8
uniprotkb:B7Z2B8
ensembl:ENSP00000219476.3
uniprotkb:O75275
uniprotkb:Q8TAZ1
Aliases for Apsi-mi:mkrn1_human(display_long)
uniprotkb:MKRN1(gene name)
psi-mi:MKRN1(display_short)
uniprotkb:RING finger protein 61(gene name synonym)
uniprotkb:RNF61(gene name synonym)
uniprotkb:RING-type E3 ubiquitin transferase makorin-1(gene name synonym)
Aliases for Bpsi-mi:tsc2_human(display_long)
uniprotkb:TSC2(gene name)
psi-mi:TSC2(display_short)
uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)
uniprotkb:TSC4(gene name synonym)
Interaction detection methodspsi-mi:"MI:0398"(two hybrid pooling approach)
First authorSakai et al. (2011)
Identifier of the publicationdoi:10.1126/scitranslmed.3002166
pubmed:21653829
imex:IM-28561
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26516092
imex:IM-28561-95
Confidence scoreintact-miscore:0.37
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:ST2
comment:"\"Library for Y2H screening used: human brain\""
dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn
dataset:"\"Autism - Autism, or autism spectrum disorder (ASD), refers to a broad range of conditions characterized by challenges with social skills, repetitive behaviors, speech and nonverbal communication.\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:4932(yeasx)
taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")
Parameters of the interaction-
Creation date2020/10/05
Update date2020/12/11
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor Bsufficient binding region:1-410
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ANucleotide sequence identification
Participant identification method for interactor BNucleotide sequence identification