Curation Details
Interaction ID: IM-28561-279

Unique identifier for interactor Auniprotkb:Q7Z6G3
Unique identifier for interactor Buniprotkb:Q92574
Alternative identifier for interactor Aintact:EBI-950070
uniprotkb:A2RRG3
uniprotkb:O75547
uniprotkb:Q6ZSK0
ensembl:ENSP00000307449.4
uniprotkb:H3BTW2
Alternative identifier for interactor Bintact:EBI-1047085
uniprotkb:Q5VVN5
intact:EBI-1386638
intact:EBI-28978933
uniprotkb:B7Z897
ensembl:ENSP00000298552.3
ensembl:ENSP00000495158.1
ensembl:ENSP00000495533.2
ensembl:ENSP00000495830.2
ensembl:ENSP00000496263.1
Aliases for Apsi-mi:neca2_human(display_long)
uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)
uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)
uniprotkb:NECAB2(gene name)
psi-mi:NECAB2(display_short)
uniprotkb:EFCBP2(gene name synonym)
Aliases for Bpsi-mi:tsc1_human(display_long)
uniprotkb:TSC1(gene name)
psi-mi:TSC1(display_short)
uniprotkb:KIAA0243(gene name synonym)
uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)
uniprotkb:TSC(gene name synonym)
Interaction detection methodspsi-mi:"MI:0398"(two hybrid pooling approach)
First authorSakai et al. (2011)
Identifier of the publicationdoi:10.1126/scitranslmed.3002166
pubmed:21653829
imex:IM-28561
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26515843
imex:IM-28561-279
Confidence scoreintact-miscore:0.37
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:ST2
comment:"\"Library for Y2H screening used: human brain\""
curation depth:imex curation
full coverage:Only protein-protein interactions
dataset:Neurodevelopmental disease - Neurodevelopmental disorders are disabilities in the functioning of the brain that affect a child's behaviour, memory or ability to learn
dataset:"\"Autism - Autism, or autism spectrum disorder (ASD), refers to a broad range of conditions characterized by challenges with social skills, repetitive behaviors, speech and nonverbal communication.\""
NCBI Taxonomy identifier for the host organismtaxid:4932(yeasx)
taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")
Parameters of the interaction-
Creation date2020/10/05
Update date2024/11/14
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor Bsufficient binding region:400-724
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor ANucleotide sequence identification
Participant identification method for interactor BNucleotide sequence identification