Curation Details
Interaction ID: IM-28529-6

Unique identifier for interactor Auniprotkb:Q05397
Unique identifier for interactor Buniprotkb:P49024
Alternative identifier for interactor Aintact:EBI-702142
intact:EBI-11047590
uniprotkb:B4E2N6
uniprotkb:F5H4S4
ensembl:ENSP00000429474.1
ensembl:ENSP00000429911.1
uniprotkb:J3QT16
uniprotkb:Q8IYN9
uniprotkb:Q14291
uniprotkb:Q9UD85
Alternative identifier for interactor Bintact:EBI-2896280
Aliases for Apsi-mi:fak1_human(display_long)
uniprotkb:PTK2(gene name)
psi-mi:PTK2(display_short)
uniprotkb:FAK(gene name synonym)
uniprotkb:FAK1(gene name synonym)
uniprotkb:pp125FAK(gene name synonym)
uniprotkb:Protein-tyrosine kinase 2(gene name synonym)
uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)
uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)
uniprotkb:p125FAK(gene name synonym)
Aliases for Bpsi-mi:paxi_chick(display_long)
uniprotkb:PXN(gene name)
psi-mi:PXN(display_short)
Interaction detection methodspsi-mi:"MI:0018"(two hybrid)
First authorThwaites et al. (2014)
Identifier of the publicationpubmed:25193659
imex:IM-28529
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9031(chick)
taxid:9031("Gallus gallus (Chicken)")
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26498316
imex:IM-28529-6
Confidence scoreintact-miscore:0.37
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 4f
comment:"\"TarP-LD interaction with FAT was evaluated and directly compared with paxillin LD2 and TarP-mutLD. A positive control Cya18-Zip/Cya25-Zip was included. By measuring β-gal production, it was clear that Cya18-TarP-LD/Cya25-FAT or Cya18-Pax-LD2/Cya25-FAT-co-expressing bacteria exhibited activity that differed significantly from the negative control strain (Fig. 4F; p < 0.01 ANOVA and Tukey-Kramer post hoc test). Importantly, the Leu-to-Ala substitution mutant did not interact with FAT.\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:316385(ecodh)
taxid:316385("Escherichia coli (strain K12 / DH10B)")
Parameters of the interaction-
Creation date2020/11/12
Update date2020/12/02
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:904..904-1052..1052
Feature(s) for interactor Bbinding-associated region:125-186
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant