| Unique identifier for interactor A | uniprotkb:P41240 |
| Unique identifier for interactor B | uniprotkb:Q7VLE8 |
| Alternative identifier for interactor A | intact:EBI-1380630 ensembl:ENSP00000454906.1 ensembl:ENSP00000220003.9 ensembl:ENSP00000414764.2 uniprotkb:Q2M3N2 uniprotkb:Q6FGZ6 |
| Alternative identifier for interactor B | intact:EBI-26445163 |
| Aliases for A | psi-mi:csk_human(display_long) uniprotkb:CSK(gene name) psi-mi:CSK(display_short) uniprotkb:C-Src kinase(gene name synonym) uniprotkb:Protein-tyrosine kinase CYL(gene name synonym) |
| Aliases for B | psi-mi:q7vle8_haedu(display_long) uniprotkb:lspA1(gene name) psi-mi:lspA1(display_short) uniprotkb:HD_1505(locus name) |
| Interaction detection methods | psi-mi:"MI:0424"(protein kinase assay) |
| First author | Dodd et al. (2014) |
| Identifier of the publication | pubmed:24902122 imex:IM-28484 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:233412(haedu) taxid:233412("Haemophilus ducreyi (strain 35000HP / ATCC 700724)") |
| Interaction types | psi-mi:"MI:0217"(phosphorylation reaction) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-26445300 imex:IM-28484-12 |
| Confidence score | intact-miscore:0.59 |
| Complex expansion | - |
| Biological role A | Enzyme |
| Biological role B | Enzyme target |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 5b comment:"\"To investigate whether YL2 could directly activate Csk, a tyrosine kinase assay that measures phosphorylation of a poly (Glu-Tyr) peptide was performed with recombinant Csk and recombinant YL2, YL2-DM, or L1. Increasing concentrations of YL2 increased Csk activity in a dose-dependent manner (Fig. 5). When 65 nM Csk and 50 nM YL2 were incubated together, therewas a 10-fold increase in Csk activity (Fig. 5A). YL2 itself had no kinase activity, and YL2-DM did not stimulate Csk activity\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2020/10/30 |
| Update date | 2020/11/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | binding-associated region:2349-2643 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Identification by antibody |
| Participant identification method for interactor B | Identification by antibody |