Curation Details
Interaction ID: IM-28371-11

Unique identifier for interactor Auniprotkb:B3CRR2
Unique identifier for interactor Buniprotkb:Q04206
Alternative identifier for interactor Aintact:EBI-26357571
Alternative identifier for interactor Bintact:EBI-73886
ensembl:ENSP00000384273.3
uniprotkb:Q6GTV1
uniprotkb:Q6SLK1
Aliases for Apsi-mi:b3crr2_oriti(display_long)
uniprotkb:OTT_0753(locus name)
Aliases for Bpsi-mi:tf65_human(display_long)
uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)
uniprotkb:RELA(gene name)
psi-mi:RELA(display_short)
uniprotkb:NFKB3(gene name synonym)
uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorEvans et al. (2018)
Identifier of the publicationimex:IM-28371
pubmed:29734393
NCBI Taxonomy identifier for interactor Ataxid:334380(Rickettsia tsutsugamushi)
taxid:334380("Orientia tsutsugamushi (strain Ikeda)")
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0914"(association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-26357829
imex:IM-28371-11
Confidence scoreintact-miscore:0.50
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:F15
comment:These results suggest that, while an intact ankyrin repeat domain is required for Ank1 to bind p65, ankyrin repeats two and three functioning in tandem are the most critical.
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-hela)
taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell)
Parameters of the interaction-
Creation date2020/09/23
Update date2020/09/25
negative Boolean valuefalse
Feature(s) for interactor Aflag tag:n-n
necessary binding region:56-121,167-201
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot