| Unique identifier for interactor A | uniprotkb:P52292 |
| Unique identifier for interactor B | uniprotkb:Q14974 |
| Alternative identifier for interactor A | intact:EBI-349938 uniprotkb:Q9BRU5 intact:EBI-28977049 uniprotkb:B9EJD6 uniprotkb:Q53YE3 ensembl:ENSP00000332455.3 ensembl:ENSP00000438483.2 ensembl:ENSP00000462331.2 ensembl:ENSP00000463602.2 ensembl:ENSP00000504655.1 ensembl:ENSP00000504685.1 intact:EBI-9377406 uniprotkb:Q6NVW7 |
| Alternative identifier for interactor B | intact:EBI-286758 uniprotkb:Q14637 uniprotkb:Q96J27 uniprotkb:Q53XN2 uniprotkb:B7ZAV6 uniprotkb:D3DTT3 ensembl:ENSP00000290158.3 ensembl:ENSP00000464042.2 intact:EBI-28976864 |
| Aliases for A | psi-mi:ima1_human(display_long) uniprotkb:KPNA2(gene name) psi-mi:KPNA2(display_short) uniprotkb:RCH1(gene name synonym) uniprotkb:SRP1(gene name synonym) uniprotkb:Karyopherin subunit alpha-2(gene name synonym) uniprotkb:SRP1-alpha(gene name synonym) uniprotkb:RAG cohort protein 1(gene name synonym) |
| Aliases for B | psi-mi:imb1_human(display_long) uniprotkb:Karyopherin subunit beta-1(gene name synonym) uniprotkb:Nuclear factor p97(gene name synonym) uniprotkb:Importin-90(gene name synonym) uniprotkb:KPNB1(gene name) psi-mi:KPNB1(display_short) uniprotkb:NTF97(gene name synonym) uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Frieman et al. (2007) |
| Identifier of the publication | imex:IM-27922 pubmed:17596301 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-25565349 imex:IM-27922-23 |
| Confidence score | intact-miscore:0.93 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 6a lane 11-14 agonist:"\"INF-beta (UniProtKB:P01574)\"" comment:"\"Moreover, Western blotting of the Flag immunoprecipitates for KPNB1 shows that in the absence of ORF6, KPNB1 associates with KPNA1 and KPNA2 but not KPNA2ΔN, confirming that the importin beta binding site of KPNA2 is necessary for KPNB1 binding. In the presence of ORF6, KPNA1 no longer binds KPNB1; however, under identical conditions, KPNA2 binds KPNB1 efficiently (Fig.6A, lanes 9 and 11). As predicted, KPNA2 binds ORF6 but no longer interacts with KPNB1 (Fig.6A, lane 13). Together, these results indicate that ORF6 binds KPNA2 as well as KPNB1; however, this binding does not reduce the KPNA1:STAT1 complex in the cell, and it reduces only the KPNA1:STAT1:KPNB1 complex.\"" curation depth:imex curation full coverage:Only protein-protein interactions dataset:Coronavirus - Interactions investigated in the context of Coronavirus |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293) taxid:9606(Homo sapiens HEK293 embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2020/04/15 |
| Update date | 2024/11/12 |
| negative Boolean value | false |
| Feature(s) for interactor A | necessary binding region:2-80 flag tag:?-? |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |