Curation Details
Interaction ID: IM-27748-24

Unique identifier for interactor Auniprotkb:Q15599
Unique identifier for interactor Buniprotkb:B7UR60
Alternative identifier for interactor Aintact:EBI-1149760
uniprotkb:D3DU84
uniprotkb:D3DU85
uniprotkb:H3BSV6
intact:EBI-15579694
ensembl:ENSP00000408005.2
uniprotkb:O00272
uniprotkb:O00556
uniprotkb:Q3KQY7
Alternative identifier for interactor Bintact:EBI-25435618
Aliases for Apsi-mi:nhrf2_human(display_long)
uniprotkb:NHERF2(gene name)
psi-mi:NHERF2(display_short)
uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)
uniprotkb:SLC9A3R2(gene name synonym)
uniprotkb:SRY-interacting protein 1(gene name synonym)
uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)
uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)
uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)
Aliases for Bpsi-mi:b7ur60_eco27(display_long)
uniprotkb:E2348C_1442(locus name)
Interaction detection methodspsi-mi:"MI:0416"(fluorescence microscopy)
First authorMartinez et al. (2010)
Identifier of the publicationpubmed:20618342
imex:IM-27748
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:574521(eco27)
taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")
Interaction typespsi-mi:"MI:0403"(colocalization)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-25436646
imex:IM-27748-24
Confidence scoreintact-miscore:0.69
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 3 suppl fig.2
comment:"\"In order to determine if the effectors colocalize with NHERF2, HeLa–NHERF2 cells were transfected with pRK5 (Fig. 3) or pRK5 expressing myc-tagged Map, MapΔC3, NleH1 and NleH1ΔC4 as well as pGFP-EspI and pGFP-EspIΔC7. Analysing the transfected cells by immunofluorescence revealed that Map colocalized with mitochondria (Fig. S1) and NHERF2 (Fig. 3). Plasma membrane-associated EspI and NleH1 colocalized with NHERF2 (Fig. 3). We observed no colocalization of NHERF2 and MapΔC3, EspIΔC7 or NleH1ΔC4 (Fig. S2).\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-hela)
taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell)
Parameters of the interaction-
Creation date2020/02/24
Update date2020/02/26
negative Boolean valuefalse
Feature(s) for interactor Aha tag:?-?
Feature(s) for interactor Bgreen fluorescent protein tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AImmunostaining
Participant identification method for interactor BImmunostaining