Curation Details
Interaction ID: IM-27561-1

Unique identifier for interactor Auniprotkb:P60953
Unique identifier for interactor Buniprotkb:P46940
Alternative identifier for interactor Aintact:EBI-81752
uniprotkb:P21181
uniprotkb:P25763
uniprotkb:Q7L8R5
uniprotkb:Q9UDI2
ensembl:ENSP00000341072.3
ensembl:ENSP00000383118.1
ensembl:ENSP00000398327.2
ensembl:ENSP00000499457.1
ensembl:ENSP00000499612.1
ensembl:ENSP00000512176.1
ensembl:ENSP00000512177.1
ensembl:ENSP00000512178.1
ensembl:ENSP00000512179.1
ensembl:ENSP00000512180.1
ensembl:ENSP00000512182.1
Alternative identifier for interactor Bintact:EBI-297509
intact:EBI-25601492
uniprotkb:A7MBM3
ensembl:ENSP00000268182.5
Aliases for Apsi-mi:cdc42_human(display_long)
uniprotkb:CDC42(gene name)
psi-mi:CDC42(display_short)
uniprotkb:G25K GTP-binding protein(gene name synonym)
Aliases for Bpsi-mi:iqga1_human(display_long)
uniprotkb:IQGAP1(gene name)
psi-mi:IQGAP1(display_short)
uniprotkb:KIAA0051(gene name synonym)
uniprotkb:p195(gene name synonym)
Interaction detection methodspsi-mi:"MI:0416"(fluorescence microscopy)
First authorBrown et al. (2008)
Identifier of the publicationimex:IM-27561
pubmed:18809683
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0403"(colocalization)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-22275428
imex:IM-27561-1
Confidence scoreintact-miscore:0.96
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 2
comment:"\"HeLa cells were fixed before and after infection with GFP EPEC (3 h) and stained for IQGAP1 (blue) and either Rac1 or Cdc42 (red) (Fig. 2). As described previously (20, 22), IQGAP1 colocalizes with both Rac1 and Cdc42 around the periphery of noninfected cells (Fig. 2). Neither Rac1 nor Cdc42 localizes at sites of EPEC adhesion (Fig. 2).\""
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-hela)
taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell)
Parameters of the interaction-
Creation date2019/12/10
Update date2024/11/12
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AImmunostaining
Participant identification method for interactor BImmunostaining