| Unique identifier for interactor A | uniprotkb:Q7DB77 |
| Unique identifier for interactor B | uniprotkb:Q14247 |
| Alternative identifier for interactor A | intact:EBI-6480811 uniprotkb:Q7A9Q1 uniprotkb:Q9R396 |
| Alternative identifier for interactor B | intact:EBI-351886 ensembl:ENSP00000301843.8 ensembl:ENSP00000500756.1 intact:EBI-3959948 uniprotkb:Q8N707 uniprotkb:Q96H99 |
| Aliases for A | psi-mi:tir_eco57(display_long) uniprotkb:tir(gene name) psi-mi:tir(display_short) uniprotkb:espE(gene name synonym) uniprotkb:Secreted effector protein Tir(gene name synonym) uniprotkb:Z5112(locus name) uniprotkb:ECs4561(locus name) |
| Aliases for B | psi-mi:src8_human(display_long) uniprotkb:CTTN(gene name) psi-mi:CTTN(display_short) uniprotkb:EMS1(gene name synonym) uniprotkb:Amplaxin(gene name synonym) uniprotkb:Oncogene EMS1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0416"(fluorescence microscopy) |
| First author | Cantarelli et al. (2007) |
| Identifier of the publication | imex:IM-27552 pubmed:17451412 |
| NCBI Taxonomy identifier for interactor A | taxid:83334(eco57) taxid:83334("Escherichia coli O157:H7") |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-22274999 imex:IM-27552-20 |
| Confidence score | intact-miscore:0.27 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 5e comment:"\"Furthermore, using immunofluorescence, Tir and tyrosine‐phosphorylated cortactin were found to colocalize beneath the attached bacteria in HeLa cells infected with DMEM‐activated EHEC for 45 min (Fig. 5E). Accordingly, due to the cortactin dephosphorylation, only Tir was detected in HeLa cells infected with EHEC for 120 min. Infection of HeLa cells with DMEM‐activated EHEC Δtir resulted in a complete failure to induce tyrosine phosphorylation of cortactin, as well as actin assembly (Fig. 5E, Δtir).\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-hela) taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell) |
| Parameters of the interaction | - |
| Creation date | 2019/12/02 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | myc tag:?-? |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Immunostaining |
| Participant identification method for interactor B | Immunostaining |