| Unique identifier for interactor A | uniprotkb:P61073 |
| Unique identifier for interactor B | uniprotkb:P08575 |
| Alternative identifier for interactor A | intact:EBI-489411 ensembl:ENSP00000241393.3 uniprotkb:Q53S69 uniprotkb:O60835 uniprotkb:P30991 uniprotkb:P56438 uniprotkb:Q9UKN2 uniprotkb:B2R5N0 uniprotkb:Q9BXA0 |
| Alternative identifier for interactor B | intact:EBI-1341 uniprotkb:A0A0A0MT22 uniprotkb:X6R433 ensembl:ENSP00000411355.3 ensembl:ENSP00000458322.2 ensembl:ENSP00000461074.2 uniprotkb:A8K7W6 uniprotkb:Q16614 uniprotkb:Q9H0Y6 |
| Aliases for A | psi-mi:cxcr4_human(display_long) uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym) uniprotkb:Fusin(gene name synonym) uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym) uniprotkb:LCR1(gene name synonym) uniprotkb:FB22(gene name synonym) uniprotkb:NPYRL(gene name synonym) uniprotkb:HM89(gene name synonym) uniprotkb:CXCR4(gene name) psi-mi:CXCR4(display_short) uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym) |
| Aliases for B | psi-mi:ptprc_human(display_long) uniprotkb:PTPRC(gene name) psi-mi:PTPRC(display_short) uniprotkb:CD45(gene name synonym) uniprotkb:T200(gene name synonym) uniprotkb:Leukocyte common antigen(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Badr et al. (2010) |
| Identifier of the publication | pubmed:21912642 imex:IM-27493 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-22197747 imex:IM-27493-1 |
| Confidence score | intact-miscore:0.40 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 3a, 3b, 5b comment:"\"Using co-immunoprecipitation and immunoblotting techniques, we showed that CXCL12 stimulation similarly induced a physical association between CXCR4 and CD45 in both MM cell lines tested (Figure 3A and 3B).\"" agonist:"\"CXCL12 (UniPRotKB: P48061)\"" comment:"\"We showed that the CXCL12-induced interaction of CXCR4 with CD45 was strongly impaired by pre-treatment with TQ (Figure 5B).\"" antagonist:"\"Thymoquinone (CHEBI:19371)\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-myeloma) taxid:9606(Homo sapiens myeloma) |
| Parameters of the interaction | - |
| Creation date | 2019/11/14 |
| Update date | 2019/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |