| Unique identifier for interactor A | uniprotkb:Q9NTX7 |
| Unique identifier for interactor B | uniprotkb:P09874 |
| Alternative identifier for interactor A | intact:EBI-722397 uniprotkb:E1P572 uniprotkb:Q96T06 intact:EBI-28979460 ensembl:ENSP00000357297.1 ensembl:ENSP00000476814.1 uniprotkb:Q6FIB2 uniprotkb:Q7L8H4 uniprotkb:Q96K03 uniprotkb:Q9NTX6 |
| Alternative identifier for interactor B | intact:EBI-355676 uniprotkb:B1ANJ4 ensembl:ENSP00000355759.5 uniprotkb:Q8IUZ9 |
| Aliases for A | psi-mi:rn146_human(display_long) uniprotkb:Dactylidin(gene name synonym) uniprotkb:RNF146(gene name) psi-mi:RNF146(display_short) uniprotkb:RING finger protein 146(gene name synonym) uniprotkb:Iduna(gene name synonym) uniprotkb:RING-type E3 ubiquitin transferase RNF146(gene name synonym) |
| Aliases for B | psi-mi:parp1_human(display_long) uniprotkb:PARP1(gene name) psi-mi:PARP1(display_short) uniprotkb:ADPRT(gene name synonym) uniprotkb:PPOL(gene name synonym) uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym) uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym) uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym) uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym) uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0096"(pull down) |
| First author | Callow et al. (2010) |
| Identifier of the publication | pubmed:21799911 imex:IM-27448 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-22117924 imex:IM-27448-6 |
| Confidence score | intact-miscore:0.56 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:suppl. fig.3 comment:"\"We used the active GST-tagged RNF146 protein and GST control protein to affinity purify interacting proteins from cell lysates of three cell lines (HEK293, HEK293 activated for Wnt signaling by LRP6 overexpression, and HCT-15). Mass spectrometric identification of protein interactors revealed seven proteins that were identified by at least 10 unique peptides in all three cell lines by GST-RNF146, but were not identified in any of the cell lines using the GST control protein (Figure S3). These specific interacting partners include PARP1 and three other proteins involved in DNA damage response.\"" variable_condition:similar result obtain inHEK293, HEK293 activated for Wnt signaling by LRP6 overexpression, and HCT-15 full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2019/10/22 |
| Update date | 2019/11/18 |
| negative Boolean value | false |
| Feature(s) for interactor A | glutathione s tranferase tag:?-? |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Sequence tag identification |
| Participant identification method for interactor B | Sequence tag identification |