| Unique identifier for interactor A | uniprotkb:Q9NTX7-2 |
| Unique identifier for interactor B | uniprotkb:O95271 |
| Alternative identifier for interactor A | intact:EBI-11750630 ensembl:ENSP00000477168.1 |
| Alternative identifier for interactor B | intact:EBI-1105254 uniprotkb:O95272 uniprotkb:Q59FX0 uniprotkb:Q4G0F2 intact:EBI-28985643 ensembl:ENSP00000311579.6 ensembl:ENSP00000493602.2 |
| Aliases for A | psi-mi:q9ntx7-2(display_long) uniprotkb:Iduna(gene name synonym) uniprotkb:RING finger protein 146(gene name synonym) uniprotkb:RING-type E3 ubiquitin transferase RNF146(gene name synonym) uniprotkb:Dactylidin(gene name synonym) uniprotkb:RNF146(gene name) psi-mi:RNF146(display_short) |
| Aliases for B | psi-mi:tnks1_human(display_long) uniprotkb:TNKS(gene name) psi-mi:TNKS(display_short) uniprotkb:PARP5A(gene name synonym) uniprotkb:PARPL(gene name synonym) uniprotkb:TIN1(gene name synonym) uniprotkb:TINF1(gene name synonym) uniprotkb:TNKS1(gene name synonym) uniprotkb:Tankyrase I(gene name synonym) uniprotkb:TNKS-1(gene name synonym) uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym) uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym) uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym) uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym) uniprotkb:Tankyrase-1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Callow et al. (2010) |
| Identifier of the publication | pubmed:21799911 imex:IM-27448 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-22117309 imex:IM-27448-5 |
| Confidence score | intact-miscore:0.40 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 5e comment:"\"We confirmed by Western analysis that RNF146 binds tankyrase by immunoprecipitating tagged RNF146 expressed in HEK293 cells (Figure 5E). Both wildtype and H53A mutant RNF146 proteins co-immunoprecipitate with endogenous TNKS1, apparently the predominant tankyrase in HEK293 cells, and with overexpressed TNKS2. Note that proteasome inhibitor ALLN weakly stabilizes TNKS2 and RNF146 when both are overexpressed.\"" variable_condition:treatment with proteasome inhibitor ALLN curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293) taxid:9606(Homo sapiens HEK293 embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2019/10/22 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | v5 tag:?-? mutation with no effect:53-53 |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |