Curation Details
Interaction ID: IM-27434-1

Unique identifier for interactor Auniprotkb:Q9UBS0
Unique identifier for interactor Buniprotkb:Q02156
Alternative identifier for interactor Aintact:EBI-3905921
uniprotkb:B2RMZ9
uniprotkb:O94809
uniprotkb:Q9UEC1
ensembl:ENSP00000308413.5
uniprotkb:B4DML8
Alternative identifier for interactor Bintact:EBI-706254
uniprotkb:B0LPH7
ensembl:ENSP00000306124.3
uniprotkb:Q32MQ3
uniprotkb:Q53SL4
uniprotkb:Q53SM5
uniprotkb:Q9UE81
Aliases for Apsi-mi:ks6b2_human(display_long)
uniprotkb:RPS6KB2(gene name)
psi-mi:RPS6KB2(display_short)
uniprotkb:STK14B(gene name synonym)
uniprotkb:70 kDa ribosomal protein S6 kinase 2(gene name synonym)
uniprotkb:S6 kinase-related kinase(gene name synonym)
uniprotkb:Serine/threonine-protein kinase 14B(gene name synonym)
uniprotkb:p70 ribosomal S6 kinase beta(gene name synonym)
Aliases for Bpsi-mi:kpce_human(display_long)
uniprotkb:nPKC-epsilon(gene name synonym)
uniprotkb:PRKCE(gene name)
psi-mi:PRKCE(display_short)
uniprotkb:PKCE(gene name synonym)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authorCarmo et al. (2010)
Identifier of the publicationpubmed:21625473
imex:IM-27434
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0914"(association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-22086386
imex:IM-27434-1
Confidence scoreintact-miscore:0.35
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 2a
comment:"\"Cells incubated in the presence or absence of FGF-2 for the times indicated were lyzed and S6K2 immunoprecipitated prior to western blotting for PKCĪµ, B-RAF or S6K2 (Fig. 2A). B-RAF and PKCĪµ associated with S6K2 in resting cells, an effect that was significantly increased by FGF-2 treatment for 10 min (Fig. 2A).\""
variable_condition:FGF2 treatment increases interaction at 10'
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-u2os)
taxid:9606(Homo sapiens U2OS osteosarcoma cell)
Parameters of the interaction-
Creation date2019/10/14
Update date2019/10/14
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot