| Unique identifier for interactor A | uniprotkb:Q2HR75 |
| Unique identifier for interactor B | uniprotkb:Q9UBU9 |
| Alternative identifier for interactor A | intact:EBI-6884751 uniprotkb:O40938 |
| Alternative identifier for interactor B | intact:EBI-398874 ensembl:ENSP00000294172.2 ensembl:ENSP00000436679.1 uniprotkb:Q99799 uniprotkb:Q9UQL2 uniprotkb:B4E269 |
| Aliases for A | psi-mi:icp27_hhv8p(display_long) uniprotkb:EB2 protein homolog(gene name synonym) uniprotkb:ORF57(orf name) |
| Aliases for B | psi-mi:nxf1_human(display_long) uniprotkb:NXF1(gene name) psi-mi:NXF1(display_short) uniprotkb:TAP(gene name synonym) uniprotkb:Tip-associating protein(gene name synonym) uniprotkb:Tip-associated protein(gene name synonym) uniprotkb:mRNA export factor TAP(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Jackson et al. (2011) |
| Identifier of the publication | pubmed:21814512 imex:IM-27426 |
| NCBI Taxonomy identifier for interactor A | taxid:868565(hhv8p) taxid:868565(Human herpesvirus 8) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-22084769 imex:IM-27426-27 |
| Confidence score | intact-miscore:0.35 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:"\"fig.7b (ii)\"" comment:"\"results showed that expression of ORF57 in the wild type 293 cell line led to the precipitation of UAP56, FSAP79 and TAP suggesting that ORF57 expression leads to the formation of an export competent ribonucleoprotein particle (Figure 7B). Similar complex formation was observed in cell lines depleted singularly for Aly and UIF, where ORF57 can precipitate UAP56, FSAP79 and TAP (Figure 7B). In contrast, depletion of Aly and UIF in combination significantly reduced the interaction between ORF57 and the hTREX components and the nuclear export factor TAP. Importantly, these data demonstrate that either Aly or UIF are required for the formation of an ORF57-mediated nuclear export competent ribonucleoprotein particle.\"" full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293t) taxid:9606(Homo sapiens HEK293T embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2019/10/09 |
| Update date | 2019/10/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | green fluorescent protein tag:?-? |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |