Curation Details
Interaction ID: IM-27419-1

Unique identifier for interactor Auniprotkb:Q14643
Unique identifier for interactor Buniprotkb:O43561
Alternative identifier for interactor Aintact:EBI-465548
uniprotkb:Q14660
uniprotkb:Q99897
ensembl:ENSP00000497605.1
uniprotkb:E7EPX7
uniprotkb:E9PDE9
Alternative identifier for interactor Bintact:EBI-1222766
uniprotkb:O43919
uniprotkb:B7WPI0
uniprotkb:C7C5T6
uniprotkb:G5E9K3
ensembl:ENSP00000354119.5
Aliases for Apsi-mi:itpr1_human(display_long)
uniprotkb:ITPR1(gene name)
psi-mi:ITPR1(display_short)
uniprotkb:INSP3R1(gene name synonym)
uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)
uniprotkb:IP3 receptor isoform 1(gene name synonym)
uniprotkb:Inositol 1,4,5 trisphosphate receptor(gene name synonym)
uniprotkb:Inositol 1,4,5-trisphosphate receptor type 1(gene name synonym)
Aliases for Bpsi-mi:lat_human(display_long)
uniprotkb:36 kDa phosphotyrosine adapter protein(gene name synonym)
uniprotkb:LAT(gene name)
psi-mi:LAT(display_short)
uniprotkb:p36-38(gene name synonym)
Interaction detection methodspsi-mi:"MI:0006"(anti bait coimmunoprecipitation)
First authordeSouza et al. (2007)
Identifier of the publicationimex:IM-27419
pubmed:18056410
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-22080929
imex:IM-27419-1
Confidence scoreintact-miscore:0.40
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig.1b
comment:"\"In ZAP-70-deficient T cells, LAT did not coimmunoprecipitate with IP3R1 (Fig. 1 B), which suggests that the association of IP3R1 with LAT is mediated by phosphorylation of LAT by ZAP-70.\""
agonist:"\"ZAP-70 (UniProtKB:P43403)\""
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:9606(human-jurkat)
taxid:9606(Homo sapiens Jurkat T-cell leukemia cell)
Parameters of the interaction-
Creation date2019/10/08
Update date2024/11/14
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot