| Unique identifier for interactor A | uniprotkb:O15037 |
| Unique identifier for interactor B | intact:EBI-4399559 |
| Alternative identifier for interactor A | intact:EBI-6148525 uniprotkb:Q86TZ6 uniprotkb:Q8IUQ2 uniprotkb:Q96BA9 ensembl:ENSP00000251343.5 ensembl:ENSP00000450799.1 ensembl:ENSP00000451106.1 |
| Alternative identifier for interactor B | dip:DIP-24261N |
| Aliases for A | psi-mi:khnyn_human(display_long) uniprotkb:KHNYN(gene name) psi-mi:KHNYN(display_short) uniprotkb:KH and NYN domain-containing protein(gene name synonym) uniprotkb:KIAA0323(gene name synonym) |
| Aliases for B | psi-mi:ubiq_human(display_short) psi-mi:EBI-4399559(display_long) |
| Interaction detection methods | psi-mi:"MI:0096"(pull down) |
| First author | Castagnoli et al. (2019) |
| Identifier of the publication | pubmed:30659753 imex:IM-26819 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-21221481 imex:IM-26819-19 |
| Confidence score | intact-miscore:0.58 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig 6f f5d f5c comment:"\". Finally, we compared the interaction of KHNYN with ubiquitinated and neddylated substrates after treatment with USP8, the deneddylating enzyme NEDP1 or MLN4924 (Fig. 6F). As shown, the interaction with flag‐tagged cellular proteins was similarly disrupted after MLN4924 or NEDP1 treatments (Fig. 6F lanes 6 and 7). Interestingly, the interaction with ubiquitinated substrates was partly affected by the removal of neddylated proteins (lane 7), suggesting that a fraction of ubiquitinated substrates recovered by pull‐down are associated with cullin‐based complexes.\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2019/02/19 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | glutathione s tranferase tag:?-? binding-associated region:598-678 |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |