| Unique identifier for interactor A | uniprotkb:Q86YC2 |
| Unique identifier for interactor B | uniprotkb:P38398 |
| Alternative identifier for interactor A | intact:EBI-1222653 uniprotkb:Q8N7Y6 uniprotkb:Q8ND31 uniprotkb:Q9H6W1 uniprotkb:A6NIE1 ensembl:ENSP00000261584.4 |
| Alternative identifier for interactor B | intact:EBI-349905 uniprotkb:Q3LRJ0 uniprotkb:O15129 uniprotkb:Q7KYU9 ensembl:ENSP00000350283.3 ensembl:ENSP00000419103.2 ensembl:ENSP00000419274.2 ensembl:ENSP00000478114.2 uniprotkb:Q3LRJ6 uniprotkb:Q6IN79 uniprotkb:Q1RMC1 uniprotkb:E9PFZ0 |
| Aliases for A | psi-mi:palb2_human(display_long) uniprotkb:PALB2(gene name) psi-mi:PALB2(display_short) uniprotkb:FANCN(gene name synonym) |
| Aliases for B | psi-mi:brca1_human(display_long) uniprotkb:BRCA1(gene name) psi-mi:BRCA1(display_short) uniprotkb:RNF53(gene name synonym) uniprotkb:RING finger protein 53(gene name synonym) uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0416"(fluorescence microscopy) |
| First author | Foo et al. (2017) |
| Identifier of the publication | pubmed:28319063 imex:IM-26811 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-21197765 imex:IM-26811-8 |
| Confidence score | intact-miscore:0.91 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 3a comment:As depicted in Figure 3a, wt PALB2 forms IRIF that largely co-localize with those of BRCA1, and PALB2-K18R and R37H behaved similarly to the wt protein. The Y28C variant was also able to form IRIF, but the foci were fewer, suggesting that its recruitment is partially impaired. In contrast, PALB2-L35P failed to form any foci, indicative of a completely abrogated recruitment. curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-eufa1341) taxid:9606(Homo sapiens EUFA1341 skin fibroblast cell) |
| Parameters of the interaction | - |
| Creation date | 2019/02/07 |
| Update date | 2024/09/03 |
| negative Boolean value | false |
| Feature(s) for interactor A | tandem tag:c-c mutation disrupting interaction:35-35 mutation with no effect:18-18 mutation decreasing interaction:28-28 mutation with no effect:37-37 |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Immunostaining |
| Participant identification method for interactor B | Immunostaining |