| Unique identifier for interactor A | uniprotkb:Q86YC2 |
| Unique identifier for interactor B | uniprotkb:Q86YC2 |
| Alternative identifier for interactor A | intact:EBI-1222653 uniprotkb:Q8N7Y6 uniprotkb:Q8ND31 uniprotkb:Q9H6W1 uniprotkb:A6NIE1 ensembl:ENSP00000261584.4 |
| Alternative identifier for interactor B | intact:EBI-1222653 uniprotkb:Q8N7Y6 uniprotkb:Q8ND31 uniprotkb:Q9H6W1 uniprotkb:A6NIE1 ensembl:ENSP00000261584.4 |
| Aliases for A | psi-mi:palb2_human(display_long) uniprotkb:PALB2(gene name) psi-mi:PALB2(display_short) uniprotkb:FANCN(gene name synonym) |
| Aliases for B | psi-mi:palb2_human(display_long) uniprotkb:PALB2(gene name) psi-mi:PALB2(display_short) uniprotkb:FANCN(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0007"(anti tag coimmunoprecipitation) |
| First author | Foo et al. (2017) |
| Identifier of the publication | pubmed:28319063 imex:IM-26811 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-21196281 imex:IM-26811-5 |
| Confidence score | intact-miscore:0.40 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig 2e comment:"\"To determine the effect of the variants on dimer/oligomer formation, we introduced the sequence alterations in a “mini-PALB2” that lacks the sequence encoded by exon 4.16 Due to the smaller size of the mini-PALB2 (PALB2Δ4) proteins, they can be clearly separated from the endogenous PALB2 on a western blot. When the proteins were transiently expressed in 293T cells and IPed, a small amount of endogenous PALB2 was co-IPed with all of them (Figure 2e and data not shown). Y28C and L35P moderately but reproducibly reduced the amount of endogenous PALB2 co-IPed, whereas K18R showed no significant effect (Figure 2e\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-293t) taxid:9606(Homo sapiens HEK293T embryonic kidney cell) |
| Parameters of the interaction | - |
| Creation date | 2019/02/07 |
| Update date | 2024/11/14 |
| negative Boolean value | false |
| Feature(s) for interactor A | binding-associated region:1-69,563-1186 mutation decreasing interaction:28-28 mutation decreasing interaction:35-35 mutation with no effect:18-18 tandem tag:c-c |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |