Curation Details
Interaction ID: IM-26811-3

Unique identifier for interactor Auniprotkb:Q3U0P1
Unique identifier for interactor Buniprotkb:P38398
Alternative identifier for interactor Aintact:EBI-21195821
uniprotkb:Q6NZG9
uniprotkb:Q7TMQ4
uniprotkb:Q8CEA9
ensembl:ENSMUSP00000095675.4
Alternative identifier for interactor Bintact:EBI-349905
uniprotkb:Q3LRJ6
uniprotkb:Q6IN79
uniprotkb:Q1RMC1
uniprotkb:E9PFZ0
ensembl:ENSP00000350283.3
ensembl:ENSP00000419103.2
ensembl:ENSP00000419274.2
ensembl:ENSP00000478114.2
uniprotkb:Q3LRJ0
uniprotkb:O15129
uniprotkb:Q7KYU9
Aliases for Apsi-mi:palb2_mouse(display_long)
uniprotkb:Palb2(gene name)
psi-mi:Palb2(display_short)
Aliases for Bpsi-mi:brca1_human(display_long)
uniprotkb:BRCA1(gene name)
psi-mi:BRCA1(display_short)
uniprotkb:RNF53(gene name synonym)
uniprotkb:RING finger protein 53(gene name synonym)
uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorFoo et al. (2017)
Identifier of the publicationpubmed:28319063
imex:IM-26811
NCBI Taxonomy identifier for interactor Ataxid:10090(mouse)
taxid:10090(Mus musculus)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0914"(association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-21195877
imex:IM-26811-3
Confidence scoreintact-miscore:0.35
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig 2c
comment:"\"Y28C and L35P both abrogated the co-IP of the endogenous BRCA1 with the ectopically expressed PALB2 proteins in 293T cells, whereas K18R, K30N and R37H did not significantly affect the complex formation (Figure 2c and data not shown). Interactions of the PALB2 variants with BRCA2 and RAD51 were all unaffected, consistent with the fact that BRCA2 binds to the C terminus of PALB2.8\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-293t)
taxid:9606(Homo sapiens HEK293T embryonic kidney cell)
Parameters of the interaction-
Creation date2019/02/07
Update date2019/02/08
negative Boolean valuefalse
Feature(s) for interactor Atandem tag:c-c
mutation disrupting interaction:28-28
mutation disrupting interaction:35-35
mutation with no effect:18-18
mutation with no effect:37-37
Feature(s) for interactor B-
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot