Curation Details
Interaction ID: IM-26811-10

Unique identifier for interactor Auniprotkb:P38398
Unique identifier for interactor Buniprotkb:Q86YC2
Alternative identifier for interactor Aintact:EBI-349905
uniprotkb:Q3LRJ6
uniprotkb:Q6IN79
uniprotkb:Q1RMC1
uniprotkb:E9PFZ0
ensembl:ENSP00000350283.3
ensembl:ENSP00000419103.2
ensembl:ENSP00000419274.2
ensembl:ENSP00000478114.2
uniprotkb:Q3LRJ0
uniprotkb:O15129
uniprotkb:Q7KYU9
Alternative identifier for interactor Bintact:EBI-1222653
uniprotkb:Q8N7Y6
uniprotkb:Q8ND31
uniprotkb:Q9H6W1
ensembl:ENSP00000261584.4
uniprotkb:A6NIE1
Aliases for Apsi-mi:brca1_human(display_long)
uniprotkb:BRCA1(gene name)
psi-mi:BRCA1(display_short)
uniprotkb:RNF53(gene name synonym)
uniprotkb:RING finger protein 53(gene name synonym)
uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)
Aliases for Bpsi-mi:palb2_human(display_long)
uniprotkb:PALB2(gene name)
psi-mi:PALB2(display_short)
uniprotkb:FANCN(gene name synonym)
Interaction detection methodspsi-mi:"MI:0416"(fluorescence microscopy)
First authorFoo et al. (2017)
Identifier of the publicationpubmed:28319063
imex:IM-26811
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0403"(colocalization)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-21197923
imex:IM-26811-10
Confidence scoreintact-miscore:0.91
Complex expansionpsi-mi:"MI:1060"(spoke expansion)
Biological role AUnspecified role
Biological role BAncillary
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 3b fig.3c
comment:"\"Consistent with our previous observations,16 EUFA1341 cells were completely defective in RAD51 IRIF formation, and the defect was fully restored upon re-expression of wt PALB2 (Figure 3b). Again, PALB2-L35P was completely unable to support RAD51 foci formation, and Y28C appeared to be hypomorphic as the protein was able to support RAD51 foci formation but the foci were evidently smaller and also modestly fewer in number (Fig. 3c).\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-eufa1341)
taxid:9606(Homo sapiens EUFA1341 skin fibroblast cell)
Parameters of the interaction-
Creation date2019/02/07
Update date2019/02/12
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor Btandem tag:c-c
mutation disrupting interaction:35-35
mutation decreasing interaction:28-28
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AImmunostaining
Participant identification method for interactor BImmunostaining