| Unique identifier for interactor A | uniprotkb:P38398 |
| Unique identifier for interactor B | uniprotkb:Q86YC2 |
| Alternative identifier for interactor A | intact:EBI-349905 uniprotkb:Q3LRJ0 uniprotkb:O15129 uniprotkb:Q7KYU9 ensembl:ENSP00000350283.3 ensembl:ENSP00000419103.2 ensembl:ENSP00000419274.2 ensembl:ENSP00000478114.2 uniprotkb:Q3LRJ6 uniprotkb:Q6IN79 uniprotkb:Q1RMC1 uniprotkb:E9PFZ0 |
| Alternative identifier for interactor B | intact:EBI-1222653 uniprotkb:Q8N7Y6 uniprotkb:Q8ND31 uniprotkb:Q9H6W1 uniprotkb:A6NIE1 ensembl:ENSP00000261584.4 |
| Aliases for A | psi-mi:brca1_human(display_long) uniprotkb:BRCA1(gene name) psi-mi:BRCA1(display_short) uniprotkb:RNF53(gene name synonym) uniprotkb:RING finger protein 53(gene name synonym) uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym) |
| Aliases for B | psi-mi:palb2_human(display_long) uniprotkb:PALB2(gene name) psi-mi:PALB2(display_short) uniprotkb:FANCN(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0416"(fluorescence microscopy) |
| First author | Foo et al. (2017) |
| Identifier of the publication | pubmed:28319063 imex:IM-26811 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0403"(colocalization) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-21197923 imex:IM-26811-10 |
| Confidence score | intact-miscore:0.91 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Ancillary |
| Experimental role A | Neutral component |
| Experimental role B | Neutral component |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:fig. 3b fig.3c comment:"\"Consistent with our previous observations,16 EUFA1341 cells were completely defective in RAD51 IRIF formation, and the defect was fully restored upon re-expression of wt PALB2 (Figure 3b). Again, PALB2-L35P was completely unable to support RAD51 foci formation, and Y28C appeared to be hypomorphic as the protein was able to support RAD51 foci formation but the foci were evidently smaller and also modestly fewer in number (Fig. 3c).\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-eufa1341) taxid:9606(Homo sapiens EUFA1341 skin fibroblast cell) |
| Parameters of the interaction | - |
| Creation date | 2019/02/07 |
| Update date | 2024/09/03 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | tandem tag:c-c mutation disrupting interaction:35-35 mutation decreasing interaction:28-28 |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Immunostaining |
| Participant identification method for interactor B | Immunostaining |