| Unique identifier for interactor A | ensembl:ENSG00000196611 |
| Unique identifier for interactor B | uniprotkb:P05412 |
| Alternative identifier for interactor A | intact:EBI-10041487 |
| Alternative identifier for interactor B | intact:EBI-852823 uniprotkb:Q96G93 uniprotkb:Q6FHM7 ensembl:ENSP00000360266.2 ensembl:ENSP00000503132.1 |
| Aliases for A | psi-mi:mmp1_human_gene(display_short) psi-mi:ENSG00000196611(display_long) |
| Aliases for B | psi-mi:jun_human(display_long) uniprotkb:Transcription factor AP-1 subunit Jun(gene name synonym) uniprotkb:JUN(gene name) psi-mi:JUN(display_short) uniprotkb:Activator protein 1(gene name synonym) uniprotkb:Proto-oncogene c-Jun(gene name synonym) uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym) uniprotkb:p39(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0402"(chromatin immunoprecipitation assay) |
| First author | Goffin et al. (2009) |
| Identifier of the publication | pubmed:20429888 imex:IM-26788 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-20620667 imex:IM-26788-3 |
| Confidence score | intact-miscore:0.69 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Gene |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f5c f6a comment:"\"Bortezomib provoked a strong increase in binding of c-Jun to the promoter region, comparable to that induced by TNF-alpha(3.7- versus 5.2-fold). Enhanced binding of c-Jun to the MMP-1 promoter was specific as the AP2 transcription factor did not exhibit an increase in binding upon either treatment, and binding of c-Jun to the MMP-2 or MMP-9 promoters was not enhanced. This was not the case since ChIP experiments revealed that bortezomib-induced binding of c-Jun to the MMP-1 promoter was not affected by TGF-beta.\"" antagonist:"\"bortezomib (CHEBI:52717)\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-fibroblast) taxid:9606(Homo sapiens diploid fibroblast) |
| Parameters of the interaction | - |
| Creation date | 2018/07/10 |
| Update date | 2024/06/06 |
| negative Boolean value | false |
| Feature(s) for interactor A | sufficient binding region:?-? |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Reverse transcription pcr |
| Participant identification method for interactor B | Reverse transcription pcr |