Curation Details
Interaction ID: IM-26767-9

Unique identifier for interactor Auniprotkb:Q96EB6
Unique identifier for interactor Buniprotkb:P37231
Alternative identifier for interactor Aintact:EBI-1802965
ensembl:ENSP00000212015.6
uniprotkb:Q2XNF6
uniprotkb:Q5JVQ0
uniprotkb:Q9GZR9
uniprotkb:Q9Y6F0
Alternative identifier for interactor Bintact:EBI-781384
uniprotkb:A8K3G6
uniprotkb:B5BUA1
uniprotkb:Q0QJH8
ensembl:ENSP00000287820.6
uniprotkb:Q96J12
uniprotkb:O00684
uniprotkb:O00710
uniprotkb:O14515
uniprotkb:Q15178
uniprotkb:Q15179
uniprotkb:Q15180
uniprotkb:Q15832
uniprotkb:Q86U60
Aliases for Apsi-mi:sir1_human(display_long)
uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)
uniprotkb:SIRT1(gene name)
psi-mi:SIRT1(display_short)
uniprotkb:SIR2L1(gene name synonym)
uniprotkb:SIR2-like protein 1(gene name synonym)
uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)
Aliases for Bpsi-mi:pparg_human(display_long)
uniprotkb:Nuclear receptor subfamily 1 group C member 3(gene name synonym)
uniprotkb:PPARG(gene name)
psi-mi:PPARG(display_short)
uniprotkb:NR1C3(gene name synonym)
Interaction detection methodspsi-mi:"MI:0007"(anti tag coimmunoprecipitation)
First authorHan et al. (2010)
Identifier of the publicationpubmed:20660480
imex:IM-26767
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-20621748
imex:IM-26767-9
Confidence scoreintact-miscore:0.58
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ABait
Experimental role BPrey
Interactor type AProtein
Interactor type BProtein
Annotations for the interactioncomment:"\"Our results showed that the SIRT1 catalytic domain is required for PPARĪ³ to recruit SIRT1 ( Figure 3 B). Collectively, these data indicate that the SIRT1 catalytic domain is necessary and sufficient for the interaction of PPARĪ³ and SIRT1.\""
figure legend:f3b
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:9606(human-hela)
taxid:9606(Homo sapiens HeLa epitheloid cervical carcinoma cell)
Parameters of the interaction-
Creation date2018/07/11
Update date2018/07/12
negative Boolean valuefalse
Feature(s) for interactor Amyc tag:?-?
necessary binding region:254-495
Feature(s) for interactor Bflag tag:?-?
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot