Curation Details
Interaction ID: IM-26693-2

Unique identifier for interactor Auniprotkb:Q9UNS2
Unique identifier for interactor Buniprotkb:Q07889
Alternative identifier for interactor Aintact:EBI-350590
uniprotkb:B4DY81
uniprotkb:B2R683
ensembl:ENSP00000268717.5
uniprotkb:O43191
uniprotkb:Q7LDR6
Alternative identifier for interactor Bintact:EBI-297487
uniprotkb:A8K2G3
uniprotkb:B4DXG2
ensembl:ENSP00000384675.2
intact:EBI-28968641
Aliases for Apsi-mi:csn3_human(display_long)
uniprotkb:COPS3(gene name)
psi-mi:COPS3(display_short)
uniprotkb:CSN3(gene name synonym)
uniprotkb:JAB1-containing signalosome subunit 3(gene name synonym)
Aliases for Bpsi-mi:sos1_human(display_long)
uniprotkb:SOS1(gene name)
psi-mi:SOS1(display_short)
Interaction detection methodspsi-mi:"MI:0096"(pull down)
First authorZarich et al. (2019)
Identifier of the publicationpubmed:30631038
imex:IM-26693
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-21018359
imex:IM-26693-2
Confidence scoreintact-miscore:0.58
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:fig. 2a
comment:"\"Cytoplasmic extracts from HeLa cells were incubated with purified GST-HD, GST-DH-PH, and GST-NDP fusion proteins coupled to glutathione–sepharose beads that were subsequently tested by means of immunoblotting with antibodies against CSN3 (Fig. 2a). Whereas purified GSTDHPH did not bind any CSN3, the GST-HD and GSTNDP peptides bound roughly similar amount of cellular CSN3 in lysates of actively growing HeLa cells (Fig. 2a, upper panel).\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2019/01/14
Update date2019/01/14
negative Boolean valuefalse
Feature(s) for interactor A-
Feature(s) for interactor Bglutathione s tranferase tag:?-?
necessary binding region:1-640
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor AWestern blot
Participant identification method for interactor BWestern blot