Curation Details
Interaction ID: IM-26660-677

Unique identifier for interactor Auniprotkb:P29350
Unique identifier for interactor Buniprotkb:P00533
Alternative identifier for interactor Aintact:EBI-78260
intact:EBI-28977917
uniprotkb:Q969V8
ensembl:ENSP00000326010.9
uniprotkb:A8K306
uniprotkb:G3V0F8
uniprotkb:Q9UK67
Alternative identifier for interactor Bintact:EBI-297353
uniprotkb:Q9BZS2
uniprotkb:Q9GZX1
uniprotkb:Q9H2C9
uniprotkb:Q9H3C9
uniprotkb:Q9UMD7
uniprotkb:Q9UMD8
uniprotkb:Q9UMG5
uniprotkb:O00688
uniprotkb:O00732
uniprotkb:P06268
uniprotkb:Q14225
uniprotkb:Q92795
intact:EBI-28985169
uniprotkb:Q68GS5
ensembl:ENSP00000275493.2
Aliases for Apsi-mi:ptn6_human(display_long)
uniprotkb:PTPN6(gene name)
psi-mi:PTPN6(display_short)
uniprotkb:HCP(gene name synonym)
uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)
uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)
uniprotkb:SH-PTP1(gene name synonym)
uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)
uniprotkb:PTP1C(gene name synonym)
Aliases for Bpsi-mi:egfr_human(display_long)
uniprotkb:ERBB1(gene name synonym)
uniprotkb:EGFR(gene name)
psi-mi:EGFR(display_short)
uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)
uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)
uniprotkb:ERBB(gene name synonym)
uniprotkb:HER1(gene name synonym)
Interaction detection methodspsi-mi:"MI:0112"(ubiquitin reconstruction)
First authorYao et al. (2017)
Identifier of the publicationimex:IM-26660
doi:10.1016/j.molcel.2016.12.004
pubmed:28065597
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0915"(physical association)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-21202178
imex:IM-26660-677
Confidence scoreintact-miscore:0.55
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role APrey
Experimental role BBait
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:sf2b
caution:"\"EBI-21202178 (From LIVIA): PTN6 has been annotated with the mutation p.Cys291Ser, however the mutation update has converted it into Gly291Ser because it cannot find a Cys in position 291, please check it and amend it.\""
curation depth:imex curation
full coverage:Only protein-protein interactions
NCBI Taxonomy identifier for the host organismtaxid:4932(yeasx)
taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")
Parameters of the interaction-
Creation date2018/10/16
Update date2024/07/10
negative Boolean valuefalse
Feature(s) for interactor Anubg:n-n
mutation with no effect:453-453,419-419
mutation with no effect:291-291
Feature(s) for interactor Bcub:c-c
mutation with no effect:855-855
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant