| Unique identifier for interactor A | uniprotkb:Q99816 |
| Unique identifier for interactor B | ensembl:ENSG00000124762 |
| Alternative identifier for interactor A | intact:EBI-346882 ensembl:ENSP00000251968.3 uniprotkb:Q9BUM5 |
| Alternative identifier for interactor B | intact:EBI-1550784 |
| Aliases for A | psi-mi:ts101_human(display_long) uniprotkb:TSG101(gene name) psi-mi:TSG101(display_short) uniprotkb:ESCRT-I complex subunit TSG101(gene name synonym) |
| Aliases for B | psi-mi:cdkn1a_human_gene(display_short) psi-mi:ENSG00000124762(display_long) |
| Interaction detection methods | psi-mi:"MI:0402"(chromatin immunoprecipitation assay) |
| First author | Lin et al. (2012) |
| Identifier of the publication | imex:IM-26634 pubmed:24244542 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-20621815 imex:IM-26634-1 |
| Confidence score | intact-miscore:0.40 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Gene |
| Annotations for the interaction | figure legend:f3a f4b comment:"\"Chromatin immunoprecipitation (ChIP) assays showed that sequences of the p21 promoter region interact directly with the TSG101 protein and identified the TSG101-binding sequence in Saos-2 as the region amplified by primer set “d” (Fig 3A). However, failure of a construct containing only the UEV domain to bind indicates that at the presence of either the PR or CC domain enables binding. Collectively these findings indicate that TSG101 contains more than one locus that allows it to interact with the p21 promoter.\"" causality statement:Q99816 activates ENSG00000124762 causality statement:down-regulates activity full coverage:Only protein-protein interactions curation depth:imex curation |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-saos-2) taxid:9606(Homo sapiens SAOS-2 osteosarcoma cell) |
| Parameters of the interaction | - |
| Creation date | 2018/07/12 |
| Update date | 2018/07/18 |
| negative Boolean value | false |
| Feature(s) for interactor A | necessary binding region:312-390 |
| Feature(s) for interactor B | sufficient binding region:?-? |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Primer specific pcr |
| Participant identification method for interactor B | Primer specific pcr |