| Unique identifier for interactor A | uniprotkb:P42224 |
| Unique identifier for interactor B | uniprotkb:Q9NX63 |
| Alternative identifier for interactor A | intact:EBI-1057697 uniprotkb:Q53S88 uniprotkb:Q53XW4 uniprotkb:B2RCA0 uniprotkb:Q9UDL5 uniprotkb:A8K989 uniprotkb:D2KFR8 uniprotkb:Q68D00 uniprotkb:D3DPI7 ensembl:ENSP00000354394.4 ensembl:ENSP00000386244.1 ensembl:ENSP00000388240.2 ensembl:ENSP00000438703.2 ensembl:ENSP00000513582.1 |
| Alternative identifier for interactor B | intact:EBI-743375 ensembl:ENSP00000262570.5 |
| Aliases for A | psi-mi:stat1_human(display_long) uniprotkb:STAT1(gene name) psi-mi:STAT1(display_short) uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym) |
| Aliases for B | psi-mi:mic19_human(display_long) uniprotkb:CHCHD3(gene name) psi-mi:CHCHD3(display_short) uniprotkb:MINOS3(gene name synonym) uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 3(gene name synonym) uniprotkb:MIC19(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0096"(pull down) |
| First author | Kalkhof et al. (2015) |
| Identifier of the publication | imex:IM-25829 pubmed:26966684 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0914"(association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-16363565 imex:IM-25829-1 |
| Confidence score | intact-miscore:0.35 |
| Complex expansion | psi-mi:"MI:1060"(spoke expansion) |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Bait |
| Experimental role B | Prey |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:T2 comment:"\"The software Protein-Protein-Interaction-Optimizer (PIPINO) was developed to perform an automated data analysis, to facilitate the selection of bona fide binding partners, and to compare the dynamic of interaction networks. In this study we investigated the STAT1 interaction network and its activation dependent dynamics. Stable isotope labeling by amino acids in cell culture (SILAC) was applied to analyze the STAT1 interactome after streptavidin pull-down of biotagged STAT1 from human embryonic kidney 293T cells with and without activation. Starting from more than 2,000 captured proteins 30 potential STAT1 interaction partners were extracted.\"" comment:"\"In this study we investigated alterations caused by a cell treatment with EPO. EPO treatment caused a STAT1 phosphorylation, activation, and translocation to the nucleus. Thus one can expect a huge impact to the STAT1 interactome. Since all three conditions were processed and analyzed simultaneously it is possible to directly determine in a single analysis whether a protein binds STAT1 (enrichment in either the STAT1 or pSTAT1 pull-down compared to the GFP control pull-down) and if the same protein does bind differentially to STAT1. A semiautomatic analysis revealed that in total 30 proteins were found to bind either STAT1 or pSTAT1 (Table 2).\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:-1(in vitro) taxid:-1(In vitro) |
| Parameters of the interaction | - |
| Creation date | 2017/08/19 |
| Update date | 2024/09/03 |
| negative Boolean value | false |
| Feature(s) for interactor A | biotin tag:?-? |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Identification by mass spectrometry |
| Participant identification method for interactor B | Identification by mass spectrometry |