Curation Details
Interaction ID: IM-25577-29

Unique identifier for interactor Auniprotkb:Q8NC69
Unique identifier for interactor Buniprotkb:Q13618
Alternative identifier for interactor Aintact:EBI-2511344
uniprotkb:Q8NBS6
uniprotkb:Q8TCA6
uniprotkb:B3KNI5
ensembl:ENSP00000347188.6
ensembl:ENSP00000384948.3
ensembl:ENSP00000417490.1
Alternative identifier for interactor Bintact:EBI-456129
ensembl:ENSP00000264414.4
uniprotkb:O75415
uniprotkb:Q569L3
uniprotkb:Q9UBI8
uniprotkb:B8ZZC3
uniprotkb:Q9UET7
uniprotkb:A8K536
Aliases for Apsi-mi:kctd6_human(display_long)
uniprotkb:KCTD6(gene name)
psi-mi:KCTD6(display_short)
uniprotkb:KCASH3 protein(gene name synonym)
uniprotkb:Potassium channel tetramerization domain-containing protein 6(gene name synonym)
Aliases for Bpsi-mi:cul3_human(display_long)
uniprotkb:CUL3(gene name)
psi-mi:CUL3(display_short)
uniprotkb:KIAA0617(gene name synonym)
Interaction detection methodspsi-mi:"MI:0040"(electron microscopy)
First authorSmaldone et al. (2016)
Identifier of the publicationimex:IM-25577
pubmed:27152988
NCBI Taxonomy identifier for interactor Ataxid:9606(human)
taxid:9606(Homo sapiens)
NCBI Taxonomy identifier for interactor Btaxid:9606(human)
taxid:9606(Homo sapiens)
Interaction typespsi-mi:"MI:0407"(direct interaction)
Source databases and identifierspsi-mi:"MI:0471"(MINT)
Interaction identifier(s) in the corresponding source databaseintact:EBI-12552309
imex:IM-25577-29
Confidence scoreintact-miscore:0.83
Complex expansion-
Biological role AUnspecified role
Biological role BUnspecified role
Experimental role ANeutral component
Experimental role BNeutral component
Interactor type AProtein
Interactor type BProtein
Annotations for the interactionfigure legend:f4
comment:"\"These results confirm the pentameric nature of KCTD6BTB and, simultaneously, the 5 : 5 stoichiometry of the KCTD6BTB – Cul3NTD complex. A deep inspection of the micrographs (Fig. 4) unravels that distinct Cul3NTD molecules assume different orientations. This indicates that Cul3 is endowed with a remarkable flexibility in these complexes.\""
full coverage:Only protein-protein interactions
curation depth:imex curation
NCBI Taxonomy identifier for the host organismtaxid:-1(in vitro)
taxid:-1(In vitro)
Parameters of the interaction-
Creation date2016/09/30
Update date2017/01/20
negative Boolean valuefalse
Feature(s) for interactor Abinding-associated region:10-110
Feature(s) for interactor Bbinding-associated region:20-381
Stoichiometry for interactor A-
Stoichiometry for interactor B-
Participant identification method for interactor APredetermined participant
Participant identification method for interactor BPredetermined participant