| Unique identifier for interactor A | uniprotkb:P00533 |
| Unique identifier for interactor B | uniprotkb:P62993 |
| Alternative identifier for interactor A | intact:EBI-297353 uniprotkb:Q9BZS2 uniprotkb:Q9GZX1 uniprotkb:Q9H2C9 uniprotkb:Q9H3C9 uniprotkb:Q9UMD7 uniprotkb:Q9UMD8 uniprotkb:Q9UMG5 uniprotkb:O00688 uniprotkb:O00732 uniprotkb:P06268 uniprotkb:Q14225 uniprotkb:Q92795 intact:EBI-28985169 uniprotkb:Q68GS5 ensembl:ENSP00000275493.2 |
| Alternative identifier for interactor B | intact:EBI-401755 uniprotkb:P29354 uniprotkb:Q14450 uniprotkb:Q63057 uniprotkb:Q63059 ensembl:ENSP00000339007.4 ensembl:ENSP00000376345.1 ensembl:ENSP00000376347.1 ensembl:ENSP00000496913.1 |
| Aliases for A | psi-mi:egfr_human(display_long) uniprotkb:ERBB1(gene name synonym) uniprotkb:EGFR(gene name) psi-mi:EGFR(display_short) uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym) uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym) uniprotkb:ERBB(gene name synonym) uniprotkb:HER1(gene name synonym) |
| Aliases for B | psi-mi:grb2_human(display_long) uniprotkb:GRB2(gene name) psi-mi:GRB2(display_short) uniprotkb:ASH(gene name synonym) uniprotkb:Adapter protein GRB2(gene name synonym) uniprotkb:SH2/SH3 adapter GRB2(gene name synonym) uniprotkb:Protein Ash(gene name synonym) |
| Interaction detection methods | psi-mi:"MI:0006"(anti bait coimmunoprecipitation) |
| First author | Song et al. (2016) |
| Identifier of the publication | imex:IM-25318 pubmed:27059931 |
| NCBI Taxonomy identifier for interactor A | taxid:9606(human) taxid:9606(Homo sapiens) |
| NCBI Taxonomy identifier for interactor B | taxid:9606(human) taxid:9606(Homo sapiens) |
| Interaction types | psi-mi:"MI:0915"(physical association) |
| Source databases and identifiers | psi-mi:"MI:0471"(MINT) |
| Interaction identifier(s) in the corresponding source database | intact:EBI-11783433 imex:IM-25318-13 |
| Confidence score | intact-miscore:0.98 |
| Complex expansion | - |
| Biological role A | Unspecified role |
| Biological role B | Unspecified role |
| Experimental role A | Prey |
| Experimental role B | Bait |
| Interactor type A | Protein |
| Interactor type B | Protein |
| Annotations for the interaction | figure legend:f4c comment:"\"In order to further confirm the low-affinity binding between EGFRvA and c-Cbl, we performed coimmunoprecipitation in U87-MG-stable cell lines (Fig. 3C,D). Consistently, we observed the similar results by using the specific antibodies. Altogether, these results indicate that the binding of EGFRvA to c-Cbl is weaker than that of EGFR to c-Cbl.\"" curation depth:imex curation full coverage:Only protein-protein interactions |
| NCBI Taxonomy identifier for the host organism | taxid:9606(human-u87) taxid:9606(Homo sapiens U-87 MG glioblastoma cell) |
| Parameters of the interaction | - |
| Creation date | 2016/06/19 |
| Update date | 2024/07/10 |
| negative Boolean value | false |
| Feature(s) for interactor A | - |
| Feature(s) for interactor B | - |
| Stoichiometry for interactor A | - |
| Stoichiometry for interactor B | - |
| Participant identification method for interactor A | Western blot |
| Participant identification method for interactor B | Western blot |